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Biological Activity for PT 1
PT 1 is an aMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.
Technical Data for PT 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PT 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PT 1
The following data is based on the product molecular weight 497.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.01 mL||10.04 mL||20.08 mL|
|5 mM||0.4 mL||2.01 mL||4.02 mL|
|10 mM||0.2 mL||1 mL||2.01 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for PT 1
References are publications that support the biological activity of the product.
Zorn and Wells (2010) Turning enzymes ON with small molecules. Nat.Chem.Biol. 6 179 PMID: 20154666
Pang et al (2007) Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J.Biol.Chem. 283 16051
Jensen et al (2015) PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. Biochem.J. 467 461 PMID: 25695398
If you know of a relevant reference for PT 1, please let us know.
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Keywords: PT 1, PT 1 supplier, AMPK, amp-activated, protein, kinase, activators, PT1, Enzyme, Substrates, /, Activators, 4039, Tocris Bioscience
2 Citations for PT 1
Citations are publications that use Tocris products. Selected citations for PT 1 include:
Huang et al (2016) The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy. J Cardiovasc Pharmacol Ther 21 70 PMID: 25868658
Asiedu et al (2017) The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development. PLoS One 12 e0169882 PMID: 28118359
Do you know of a great paper that uses PT 1 from Tocris? Please let us know.
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Literature in this Area
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