PSN 375963 hydrochloride

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Cat.No. 3353 - PSN 375963 hydrochloride | C17H23N3O.HCl | CAS No. 388575-52-8
Description: GPR119 receptor agonist
Chemical Name: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

GPR119 receptor agonist (EC50 values are 8.4 and 7.9 μM at human and mouse receptors respectively). Displays similar potency to the endogenous ligand oleylethanolamide (OEA) (Cat. No. 1484).

Compound Libraries

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Technical Data

M. Wt 321.84
Formula C17H23N3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 388575-52-8
PubChem ID 56972228
Smiles CCCCC(CC3)CCC3C1=NC(C2=CC=NC=C2)=NO1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.18 100
ethanol 32.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 321.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.54 mL 31.07 mL
5 mM 0.62 mL 3.11 mL 6.21 mL
10 mM 0.31 mL 1.55 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References are publications that support the biological activity of the product.

Overton et al (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3 167 PMID: 16517404

Ning et al (2008) Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on Ins secretion in MIN6c4 Insoma cells. Br.J.Pharmacol. 155 1056 PMID: 18724386

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GPCR Product Listing

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