PSN 375963 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3353 - PSN 375963 hydrochloride | C17H23N3O.HCl | CAS No. 388575-52-8
Description: GPR119 receptor agonist
Chemical Name: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GPR119 receptor agonist (EC50 values are 8.4 and 7.9 μM at human and mouse receptors respectively). Displays similar potency to the endogenous ligand oleylethanolamide (OEA) (Cat. No. 1484).

Compound Libraries

PSN 375963 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 321.84
Formula C17H23N3O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 388575-52-8
PubChem ID 56972228
InChI Key ONDLSENXTCSHGC-UHFFFAOYSA-N
Smiles CCCCC(CC3)CCC3C1=NC(C2=CC=NC=C2)=NO1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 32.18 100
DMSO 32.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 321.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.54 mL 31.07 mL
5 mM 0.62 mL 3.11 mL 6.21 mL
10 mM 0.31 mL 1.55 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Overton et al (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3 167 PMID: 16517404

Ning et al (2008) Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br.J.Pharmacol. 155 1056 PMID: 18724386


If you know of a relevant reference for PSN 375963 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all GPR119 Agonists

Keywords: PSN 375963 hydrochloride, PSN 375963 hydrochloride supplier, GPR119, receptors, agonists, PSN375963, hydrochloride, 3353, Tocris Bioscience

Citations for PSN 375963 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for PSN 375963 hydrochloride. Do you know of a great paper that uses PSN 375963 hydrochloride from Tocris? Please let us know.

Reviews for PSN 375963 hydrochloride

There are currently no reviews for this product. Be the first to review PSN 375963 hydrochloride and earn rewards!

Have you used PSN 375963 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling