PSC 833

Pricing Availability   Qty
Description: Inhibitor of P-gp-mediated MDR
Alternative Names: Valspodar
Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews (1)
Literature (1)

Biological Activity for PSC 833

PSC 833 is a P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).

Technical Data for PSC 833

M. Wt 1214.62
Formula C63H111N11O12
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 121584-18-7
PubChem ID 5281884
InChI Key YJDYDFNKCBANTM-QCWCSKBGSA-N
Smiles C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PSC 833

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.86 4

Preparing Stock Solutions for PSC 833

The following data is based on the product molecular weight 1214.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.04 mM 20.58 mL 102.91 mL 205.83 mL
0.2 mM 4.12 mL 20.58 mL 41.17 mL
0.4 mM 2.06 mL 10.29 mL 20.58 mL
2 mM 0.41 mL 2.06 mL 4.12 mL

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Product Datasheets for PSC 833

Certificate of Analysis / Product Datasheet
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References for PSC 833

References are publications that support the biological activity of the product.

Song et al (1998) Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J.Pharmacol.Exp.Ther. 287 963 PMID: 9864280

Goda et al (2007) Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 320 81 PMID: 17050779

Shen et al (2008) Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 324 95 PMID: 17947497

Shen et al (2009) Dynamic assessment of mitoxan. resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 330 423 PMID: 19423841


If you know of a relevant reference for PSC 833, please let us know.

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Keywords: PSC 833, PSC 833 supplier, PSC833, P-glycoprotein, inhibitors, inhibits, P-gp, cyclosporin, A, analog, analogue, ABCB1, Valspodar, Multidrug, Transporters, 4042, Tocris Bioscience

8 Citations for PSC 833

Citations are publications that use Tocris products. Selected citations for PSC 833 include:

Mark C et al (2021) Biomaterial screening of protein coatings and peptide additives: towards a simple synthetic mimic of a complex natural coating for a bio-artificial kidney. Biomater Sci 9 2209-2220 PMID: 33506836

Jos et al (2021) Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies. J Pharm Sci 110 1601-1614 PMID: 33545187

Slosky et al (2013) Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Mol Pharmacol 84 774 PMID: 24019224

Elbaradie et al (2013) Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-OE involves differential regulation of plasma membrane associated estrogen receptors. Sci Rep 1833 1165 PMID: 23305904


Do you know of a great paper that uses PSC 833 from Tocris? Please let us know.

Reviews for PSC 833

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Highly stable.
By Anonymous on 05/09/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Human brain endothelial cell

50 mg/kg of PSC833 for 15 minutes

PMID: 27043281
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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