PSC 833
Biological Activity
P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101).
Technical Data
| M. Wt | 1214.62 |
| Formula | C63H111N11O12 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 121584-18-7 |
| PubChem ID | 5281884 |
| InChI Key | YJDYDFNKCBANTM-QCWCSKBGSA-N |
| Smiles | C[C@H](C)[C@@H](C1=O)NC([C@H](CC(C)C)N(C(CN(C([C@H]([C@H](C)C)NC([C@H]([C@]([C@H](C)C/C=C/C)=O)N(C([C@H]([C@@H](C)C)N(C([C@H](CC(C)C)N(C([C@H](CC(C)C)N(C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N1C)=O)=O)=O)C)=O)C)=O)C)=O)C)=O)=O)C)=O)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.86 | 4 |
Preparing Stock Solutions
The following data is based on the product molecular weight 1214.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.82 mL | 4.12 mL | 8.23 mL |
| 5 mM | 0.16 mL | 0.82 mL | 1.65 mL |
| 10 mM | 0.08 mL | 0.41 mL | 0.82 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Song et al (1998) Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J.Pharmacol.Exp.Ther. 287 963 PMID: 9864280
Goda et al (2007) Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 320 81 PMID: 17050779
Shen et al (2008) Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 324 95 PMID: 17947497
Shen et al (2009) Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 330 423 PMID: 19423841
If you know of a relevant reference for PSC 833, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PSC 833, PSC 833 supplier, PSC833, P-glycoprotein, inhibitors, inhibits, P-gp, cyclosporin, A, analog, analogue, ABCB1, Valspodar, Multidrug, Transporters, 4042, Tocris Bioscience
5 Citations for PSC 833
Citations are publications that use Tocris products. Selected citations for PSC 833 include:
Lipka et al (2012) Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells. PLoS One 7 e40853 PMID: 22815843
Slosky et al (2013) Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Mol Pharmacol 84 774 PMID: 24019224
Ong et al (2013) Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model. Antimicrob Agents Chemother 57 2535 PMID: 23507281
Kim and Bynoe (2016) A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest 126 1717 PMID: 27043281
Elbaradie et al (2013) Sex-specific response of rat costochondral cartilage growth plate chondrocytes to 17β-estradiol involves differential regulation of plasma membrane associated estrogen receptors. Sci Rep 1833 1165 PMID: 23305904
Do you know of a great paper that uses PSC 833 from Tocris? Please let us know.
Reviews for PSC 833
There are currently no reviews for this product. Be the first to review PSC 833 and earn rewards!
Have you used PSC 833?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
