PSB CB5

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Cat.No. 6372 - PSB CB5 | C20H17ClN2O2S | CAS No. 1627710-30-8
Description: Selective GPR18 antagonist
Chemical Name: (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.

Technical Data

M. Wt 384.88
Formula C20H17ClN2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1627710-30-8
PubChem ID 85469571
InChI Key XJBQRMOGMULGPP-PDGQHHTCSA-N
Smiles O=C(N1C(SCCC1)=N/2)C2=C\C3=CC(OCC4=CC=C(Cl)C=C4)=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.7 20

Preparing Stock Solutions

The following data is based on the product molecular weight 384.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.99 mL 64.96 mL 129.91 mL
1 mM 2.6 mL 12.99 mL 25.98 mL
2 mM 1.3 mL 6.5 mL 12.99 mL
10 mM 0.26 mL 1.3 mL 2.6 mL

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References

References are publications that support the biological activity of the product.

Rempel et al (2014) Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm. 5 632

Flegel et al (2016) Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 6 32255 PMID: 27572937


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Keywords: PSB CB5, PSB CB5 supplier, PSBCB5, GPR18, selective, antagonist, Other, Cannabinoids, 6372, Tocris Bioscience

Citations for PSB CB5

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Literature in this Area

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