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Selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 384.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.99 mL||64.96 mL||129.91 mL|
|1 mM||2.6 mL||12.99 mL||25.98 mL|
|2 mM||1.3 mL||6.5 mL||12.99 mL|
|10 mM||0.26 mL||1.3 mL||2.6 mL|
References are publications that support the biological activity of the product.
Rempel et al (2014) Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm. 5 632
Flegel et al (2016) Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 6 32255 PMID: 27572937
If you know of a relevant reference for PSB CB5, please let us know.
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Keywords: PSB CB5, PSB CB5 supplier, PSBCB5, GPR18, selective, antagonist, Other, Cannabinoids, 6372, Tocris Bioscience
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