Discontinued Product

N-Arachidonylglycine (Cat. No. 1445) has been withdrawn from sale for commercial reasons.
Description: GPR18 agonist; endocannabinoid
Alternative Names: NAGly
Chemical Name: N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for N-Arachidonylglycine

N-Arachidonylglycine is a GPR18 agonist (EC50 = 44.5 nM). Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki > 10 μM), VR1 receptors (EC50 > 10 μM) and anandamide transporters (IC50 > 50 μM) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.

Technical Data for N-Arachidonylglycine

M. Wt 361.52
Formula C22H35NO3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 179113-91-8
PubChem ID 5283389

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for N-Arachidonylglycine

References for N-Arachidonylglycine

References are publications that support the biological activity of the product.

Burnstein et al (2000) Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 61 29 PMID: 10785540

Edington et al (2009) Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J.Biol.Chem. 284 36424 PMID: 19875446

Huang et al (2001) Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J.Biol.Chem. 276 42639 PMID: 11518719

Sheskin et al (1997) Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J.Med.Chem. 40 659 PMID: 9057852

Kohno et al (2006) Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 347 827 PMID: 16844083

McHugh et al (2012) Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells Br.J.Pharmacol. 2414 165 PMID: 21595653

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Keywords: N-Arachidonylglycine, N-Arachidonylglycine supplier, endocannabinoids, Suppresses, pain, vivo, Receptors, NAGly, Other, Cannabinoids, Glycine, Transporters, 1445, Tocris Bioscience

Citations for N-Arachidonylglycine

Citations are publications that use Tocris products.

Currently there are no citations for N-Arachidonylglycine.

Reviews for N-Arachidonylglycine

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Product used to significantly inhibit TNF alpha and IFN gamma production.
By Anonymous on 08/29/2019
Species: Human

Product used to significantly inhibit TNF alpha and IFN gamma production.It shows potential as a therapeutic treatment for chronic inflammation and interactive effects on immune system.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.