PSB 12379

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Description: Ecto-5'-nucleotidase (CD73) inhibitor
Chemical Name: N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity for PSB 12379

PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.

Technical Data for PSB 12379

M. Wt 559.31
Formula C18H21N5Na2O9P2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 131648246
InChI Key CGXINRNHTNDEBI-BUPZQQHBSA-L
Smiles O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PSB 12379

Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Product Datasheets for PSB 12379

Certificate of Analysis / Product Datasheet
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References for PSB 12379

References are publications that support the biological activity of the product.

Bhattarai et al (2015) α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 58 6248 PMID: 26147331

Weinmann et al (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578


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Keywords: PSB 12379, PSB 12379 supplier, PSB12379, selective, high, affinity, CD73, inhibitors, inhibits, 1802226-78-3, NTPDase, 6083, Tocris Bioscience

2 Citations for PSB 12379

Citations are publications that use Tocris products. Selected citations for PSB 12379 include:

Istvan et al (2022) Microglial control of neuronal development via somatic purinergic junctions. Cell Rep 40 111369 PMID: 36130488

Hyunjung et al (2020) Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition From Habitual to Goal-Directed Reward-Seeking Behavior. Biol Psychiatry 88 797-808 PMID: 32564901


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.