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Biological Activity for PSB 12379
PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.
Technical Data for PSB 12379
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB 12379
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 10mM)|
References for PSB 12379
References are publications that support the biological activity of the product.
Bhattarai et al (2015) α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 58 6248 PMID: 26147331
Weinmann et al (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578
If you know of a relevant reference for PSB 12379, please let us know.
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Keywords: PSB 12379, PSB 12379 supplier, PSB12379, selective, high, affinity, CD73, inhibitors, inhibits, 1802226-78-3, NTPDase, 6083, Tocris Bioscience
Citations for PSB 12379
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Literature in this Area
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