PSB 12379

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Cat.No. 6083 - PSB 12379 | C18H21N5Na2O9P2
Description: Ecto-5'-nucleotidase (CD73) inhibitor
Chemical Name: N6-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt
Purity: ≥98% (HPLC)
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Biological Activity

Selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (Ki values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.

Technical Data

M. Wt 559.31
Formula C18H21N5Na2O9P2
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in water (supplied pre-dissolved at a concentration of 10mM)

Preparing Stock Solutions

The following data is based on the product molecular weight 559.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.94 mL 17.88 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
10 mM 0.18 mL 0.89 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bhattarai et al (2015) α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 58 6248 PMID: 26147331

Weinmann et al (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578


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Keywords: PSB 12379, supplier, PSB12379, selective, high, affinity, CD73, inhibitors, inhibits, NTPDase, NTPDase, Tocris Bioscience

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