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Description: Negative control for PROTAC®(H-PGDS)-7 (Cat. No. 8004)
Chemical Name: N-[4-[4-[[4-[2,3-Dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for PROTAC®(H-PGDS)-8

PROTAC®(H-PGDS)-8 is the negative control for PROTAC®(H-PGDS)-7 (Cat. No. 8004).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from National Institute of Health Sciences, Japan and Tsuzuki Gakuen.

Technical Data for PROTAC®(H-PGDS)-8

M. Wt 756.82
Formula C41H40N8O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2761281-51-8
PubChem ID 166626647
Smiles O=C(C1=CN=C(OC2=CC=CC=C2)N=C1)NC3=CC=C(N4CCC(CC4)C(N5CCN(CC5)C(C=CC=C6C(N7C8C(N(C)C(CC8)=O)=O)=O)=C6C7=O)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PROTAC®(H-PGDS)-8

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 75.68 100

Preparing Stock Solutions for PROTAC®(H-PGDS)-8

The following data is based on the product molecular weight 756.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.32 mL 6.61 mL 13.21 mL
5 mM 0.26 mL 1.32 mL 2.64 mL
10 mM 0.13 mL 0.66 mL 1.32 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets for PROTAC®(H-PGDS)-8

References for PROTAC®(H-PGDS)-8

References are publications that support the biological activity of the product.

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View Related Products by Target

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Citations for PROTAC®(H-PGDS)-8

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia