Propofol

Discontinued Product

Unfortunately Propofol (Cat. No. 0939) has been withdrawn from sale for commercial reasons.
Cat.No. 0939 - Propofol | C12H18O | CAS No. 2078-54-8
Chemical Name: 2,6-Diisopropylphenol
Datasheet
Citations

Biological Activity

Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABAA receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X4 receptor-mediated currents in P2X4-HEK293 cells.

Technical Data

M. Wt 178.27
Formula C12H18O
Storage Store at RT
CAS Number 2078-54-8
Smiles OC1=C(C(C)C)C=CC=C1C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 178.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.61 mL 28.05 mL 56.09 mL
5 mM 1.12 mL 5.61 mL 11.22 mL
10 mM 0.56 mL 2.8 mL 5.61 mL
50 mM 0.11 mL 0.56 mL 1.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Nadeson and Goodchild (1997) Antinociceptive properties of propofol: involvement of spinal cord γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 282 1181 PMID: 9316824

Orser et al (1995) Inhibition by propofol (2,6-di-isopropylphenol) of the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br.J.Pharmacol. 116 1761 PMID: 8528557

Takahashi et al (1994) The effects of propofol and enflurane on single calcium channel currents of guinea-pig isolated ventricular myocytes. Br.J.Pharmacol. 111 1147 PMID: 8032601

Tomioka et al (2000) Propofol potentiates ATP-activated currents of recombinant P2X4 receptor channels expressed in human embryonic kidney 293 cells. Neurosci.Lett. 284 167 PMID: 10773425

Keywords: Propofol, supplier, Tocris Bioscience

Citations for Propofol

Citations are publications that use Tocris products.

Currently there are no citations for Propofol.

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