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Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABAA receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X4 receptor-mediated currents in P2X4-HEK293 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Nadeson and Goodchild (1997) Antinociceptive properties of PropF.: involvement of spinal cord γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 282 1181 PMID: 9316824
Orser et al (1995) Inhibition by PropF. (2,6-di-isopropylphenol) of the N-MthD.-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br.J.Pharmacol. 116 1761 PMID: 8528557
Takahashi et al (1994) The effects of PropF. and enfl. on single calcium channel currents of guinea-pig isolated ventricular myocytes. Br.J.Pharmacol. 111 1147 PMID: 8032601
Tomioka et al (2000) PropF. potentiates ATP-activated currents of recombinant P2X4 receptor channels expressed in human embryonic kidney 293 cells. Neurosci.Lett. 284 167 PMID: 10773425
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Keywords: Propofol, Propofol supplier, , Tocris Bioscience
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