Prion Protein 106-126 (human)

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Cat.No. 3491 - Prion Protein 106-126 (human) | Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly | CAS No. 148439-49-0
Description: Prion protein fragment
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Prion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.

Technical Data

M. Wt 1912.26
Formula C80H138N26O24S2
Sequence KTNMKHMAGAAAAGAVVGGLG
Storage Desiccate at -20°C
CAS Number 148439-49-0
PubChem ID 16135249
InChI Key XPZWWTIIKSODDO-MBNDGZRNSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Forloni et al (1993) Neurotoxicity of a prion protein fragment. Nature 362 543 PMID: 8464494

Pietri et al (2006) Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J.Biol.Chem. 281 28470 PMID: 16864581

Bai et al (2008) p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells. Neurosci.Res. 62 9 PMID: 18602709


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Keywords: Prion Protein 106-126 (human), Prion Protein 106-126 (human) supplier, Prion, protein, fragment, PrPSc, Antiprion, Neuronal, Metabolism, Protein, 3491, Tocris Bioscience

1 Citation for Prion Protein 106-126 (human)

Citations are publications that use Tocris products. Selected citations for Prion Protein 106-126 (human) include:

Domizio et al (2012) Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem 287 736 PMID: 22102410


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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease

Pathways for Prion Protein 106-126 (human)

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.