Pridopidine

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Cat.No. 7630 - Pridopidine | C15H23NO2S | CAS No. 346688-38-8
Description: Highly selective σ1 agonist
Alternative Names: PL-101, ACR16, Huntexil
Chemical Name: 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity for Pridopidine

Pridopidine is a selective high affinity σ-1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ~30-fold and ~100-fold selectivity over the dopamine D3 receptor and the D2 receptor, respectively. Pridopidine is a low affinity dopamine D2 receptor antagonist (Ki (low) = 17.5 μM; Ki (high) = 7.5 μM). Pridopidine upregulates gene expression induced by BDNF in rat striatum in vivo in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington's disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models in vitro and in vivo. Orally bioavailable.

Technical Data for Pridopidine

M. Wt 281.42
Formula C15H23NO2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 346688-38-8
PubChem ID 9795739
InChI Key YGKUEOZJFIXDGI-UHFFFAOYSA-N
Smiles CS(C1=CC(C2CCN(CCC)CC2)=CC=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Pridopidine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.14 100
ethanol 28.14 100

Preparing Stock Solutions for Pridopidine

The following data is based on the product molecular weight 281.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.77 mL 35.53 mL
5 mM 0.71 mL 3.55 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References for Pridopidine

References are publications that support the biological activity of the product.

Ionescu et al (2019) Targeting the sigma-1 receptor via pridopidine ameliorates central features of ALS pathology in a SOD1G93A model. Cell Death Dis. 10 210 PMID: 30824685

Geva et al (2016) Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum.Mol.Genet. 25 3975 PMID: 27466197

Ye et al (2020) Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases. J.Med.Chem. 63 15187 PMID: 33111525

Sahlholm et al (2013) The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor. Mol.Psychiatry 18 12 PMID: 22349783

Ryskamp et al (2017) The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol.Dis. 97 46 PMID: 27818324


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Citations for Pridopidine

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