PR 619

Pricing Availability Delivery Time Qty
Cat.No. 4482 - PR 619 | C7H5N5S2 | CAS No. 2645-32-1
Description: Broad spectrum DUB inhibitor
Chemical Name: 2,6-Diamino-3,5-dithiocyanopyridine
Purity: ≥98% (HPLC)

Biological Activity

Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.

Technical Data

M. Wt 223.28
Formula C7H5N5S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2645-32-1
PubChem ID 2817763
Smiles NC1=C(SC#N)C=C(SC#N)C(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.23 10

Preparing Stock Solutions

The following data is based on the product molecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.48 mL 22.39 mL 44.79 mL
5 mM 0.9 mL 4.48 mL 8.96 mL
10 mM 0.45 mL 2.24 mL 4.48 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401 PMID: 22118674

Seiberlich et al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta 1823 2057 PMID: 22565157

If you know of a relevant reference for PR 619, please let us know.

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Citations for PR 619

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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