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Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 223.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||44.79 mL||223.93 mL||447.87 mL|
|0.5 mM||8.96 mL||44.79 mL||89.57 mL|
|1 mM||4.48 mL||22.39 mL||44.79 mL|
|5 mM||0.9 mL||4.48 mL||8.96 mL|
References are publications that support the biological activity of the product.
Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401 PMID: 22118674
Seiberlich et al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta 1823 2057 PMID: 22565157
If you know of a relevant reference for PR 619, please let us know.
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Keywords: PR 619, PR 619 supplier, PR619, inhibitors, DUBs, deubiquitinating, enzymes, deubiquitination, proteasome, inhibits, broad, spectrum, proteases, Deubiquitinating, Enzymes, 4482, Tocris Bioscience
1 Citation for PR 619
Citations are publications that use Tocris products. Selected citations for PR 619 include:
Saldate et al (2018) The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology. J Biol Chem 293 2232 PMID: 29269412
Do you know of a great paper that uses PR 619 from Tocris? Please let us know.
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