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Potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 694.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.44 mL||7.2 mL||14.4 mL|
|5 mM||0.29 mL||1.44 mL||2.88 mL|
|10 mM||0.14 mL||0.72 mL||1.44 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
References are publications that support the biological activity of the product.
Lambrecht et al (2000) The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19 PMID: 10650184
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Keywords: PPNDS, PPNDS supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, P2X, 1309, Tocris Bioscience
1 Citation for PPNDS
Citations are publications that use Tocris products. Selected citations for PPNDS include:
Madoux et al (2014) Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers 102 396 PMID: 25048711
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.