PPNDS

Pricing Availability   Qty
Description: Potent and selective P2X1 antagonist
Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity for PPNDS

PPNDS is a potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.

Technical Data for PPNDS

M. Wt 694.36
Formula C18H11N4Na4O14PS2
Storage Desiccate at -20°C
CAS Number 1021868-77-8
PubChem ID 2750
InChI Key XHWIRFKQZFSILU-MKMLRUMESA-J
Smiles CC1=C(O)C(C=O)=C(COP(O[Na])(O[Na])=O)C(/N=N/C2=CC3=C(C=C(C=C3C(S(=O)(O[Na])=O)=C2)[N+]([O-])=O)S(=O)(O[Na])=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PPNDS

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for PPNDS

The following data is based on the product molecular weight 694.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.2 mL 14.4 mL
5 mM 0.29 mL 1.44 mL 2.88 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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References for PPNDS

References are publications that support the biological activity of the product.

Lambrecht et al (2000) The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19 PMID: 10650184


If you know of a relevant reference for PPNDS, please let us know.

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Keywords: PPNDS, PPNDS supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, P2X, 1309, Tocris Bioscience

1 Citation for PPNDS

Citations are publications that use Tocris products. Selected citations for PPNDS include:

Madoux et al (2014) Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers 102 396 PMID: 25048711


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Reviews for PPNDS

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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