PPNDS

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Cat.No. 1309 - PPNDS | C18H11N4Na4O14PS2 | CAS No. 1021868-77-8
Description: Potent, selective P2X1 antagonist
Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.

Technical Data

M. Wt 694.36
Formula C18H11N4Na4O14PS2
Storage Desiccate at -20°C
CAS Number 1021868-77-8
PubChem ID 2750
InChI Key YZFWTZACSRHJQD-UHFFFAOYSA-N
Smiles [Na+].[Na+].[Na+].[Na+].CC1=C(O)C(C=O)=C(COP([O-])([O-])=O)C(N=NC2=CC3=C(C=C(C=C3C(=C2)S([O-])(=O)=O)[N+]([O-])=O)S([O-])(=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 694.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.2 mL 14.4 mL
5 mM 0.29 mL 1.44 mL 2.88 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lambrecht et al (2000) The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19 PMID: 10650184


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Keywords: PPNDS, supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, P2X, Receptors, P2X, Receptors, Tocris Bioscience

1 Citation for PPNDS

Citations are publications that use Tocris products. Selected citations for PPNDS include:

Madoux et al (2014) Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers 102 396 PMID: 25048711


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