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Description: Potent and selective P2X1 antagonist
Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt
Biological Activity for PPNDS
PPNDS is a potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.
Technical Data for PPNDS
| M. Wt | 694.36 |
| Formula | C18H11N4Na4O14PS2 |
| Storage | Desiccate at -20°C |
| CAS Number | 1021868-77-8 |
| PubChem ID | 2750 |
| InChI Key | XHWIRFKQZFSILU-MKMLRUMESA-J |
| Smiles | CC1=C(O)C(C=O)=C(COP(O[Na])(O[Na])=O)C(/N=N/C2=CC3=C(C=C(C=C3C(S(=O)(O[Na])=O)=C2)[N+]([O-])=O)S(=O)(O[Na])=O)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PPNDS
References for PPNDS
References are publications that support the biological activity of the product.
Lambrecht et al (2000) The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors. Eur.J.Pharmacol. 387 R19 PMID: 10650184
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Keywords: PPNDS, PPNDS supplier, Potent, selective, P2X1, antagonists, Receptors, Purinergic, purinoceptors, P2X, 1309, Tocris Bioscience
1 Citation for PPNDS
Citations are publications that use Tocris products. Selected citations for PPNDS include:
Madoux et al (2014) Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers 102 396 PMID: 25048711
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.