POM 1

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Cat.No. 2689 - POM 1 | H2O40Na6W12 | CAS No. 12141-67-2
Description: Inhibitor of E-NTPDases
Alternative Names: Sodium polyoxotungstate
Chemical Name: Sodium metatungstate
Datasheet
Citations (12)
Reviews (1)
Literature (2)

Biological Activity

Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data

M. Wt 2986.01
Formula H2O40Na6W12
Storage Store at RT
CAS Number 12141-67-2
PubChem ID 71311259
InChI Key YVQUUPJGDSQKML-UHFFFAOYSA-N
Smiles O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 298.6 100

Preparing Stock Solutions

The following data is based on the product molecular weight 2986.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.67 mL 3.35 mL
5 mM 0.07 mL 0.33 mL 0.67 mL
10 mM 0.03 mL 0.17 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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References

References are publications that support the biological activity of the product.

Muller et al (2006) Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 16 5943 PMID: 16997558

Grenz et al (2007) Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21 2863 PMID: 17442731

Wall et al (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. 55 1251 PMID: 18768144


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Keywords: POM 1, POM 1 supplier, inhibitors, inhibits, E-NTPDases, ATPases, POM1, Sodium, polyoxotungstate, NTPDase, 2689, Tocris Bioscience

12 Citations for POM 1

Citations are publications that use Tocris products. Selected citations for POM 1 include:

Burr and Parekkadan (2019) Kinetics of MSC-based enzyme therapy for immunoregulation. J Transl Med 17 263 PMID: 31409424

Hirata et al (2018) CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell Stem Cell 22 445 PMID: 29456159

Sassi et al (2014) Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest 124 5385 PMID: 25401477

Aho et al (2016) Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal 12 575 PMID: 27030122


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Reviews for POM 1

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POM-1 inhibits PBMCs CD39 activity.
By Anonymous on 02/21/2019
Assay Type: Ex Vivo
Species: Human
Cell Line/Tissue: PBMCs

Human PBMCs were incubated with 10 μM POM-1 for 30 minutes to inhibit CD39 ATPase activity. POM-1 caused a 80% inhibition of PBMCs ATPase activity.

PBMCs were isolated from healthy subjects and from multiple sclerosis patients and CD39 activity was measured by the Malachite Green Phosphate Assay. Cells were washed in phosphate-free buffer and incubated with ATP (250 μM) for 30 minutes at 37ºC. To selectively assess CD39 ATPase activity, POM-1 (10 μM) was added while cells were incubated with ATP.

PMID: 30783191
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