POM 1

Pricing Availability   Qty
Description: Inhibitor of E-NTPDases
Alternative Names: Sodium polyoxotungstate
Chemical Name: Sodium metatungstate
Datasheet
Citations (12)
Reviews (1)
Literature (1)

Biological Activity for POM 1

POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data for POM 1

M. Wt 2986.01
Formula H2O40Na6W12
Storage Store at RT
CAS Number 12141-67-2
PubChem ID 71311259
InChI Key YVQUUPJGDSQKML-UHFFFAOYSA-N
Smiles O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for POM 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 298.6 100

Preparing Stock Solutions for POM 1

The following data is based on the product molecular weight 2986.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.67 mL 3.35 mL
5 mM 0.07 mL 0.33 mL 0.67 mL
10 mM 0.03 mL 0.17 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets for POM 1

Certificate of Analysis / Product Datasheet
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References for POM 1

References are publications that support the biological activity of the product.

Muller et al (2006) Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 16 5943 PMID: 16997558

Grenz et al (2007) Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21 2863 PMID: 17442731

Wall et al (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. 55 1251 PMID: 18768144


If you know of a relevant reference for POM 1, please let us know.

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Keywords: POM 1, POM 1 supplier, inhibitors, inhibits, E-NTPDases, ATPases, POM1, Sodium, polyoxotungstate, NTPDase, 2689, Tocris Bioscience

12 Citations for POM 1

Citations are publications that use Tocris products. Selected citations for POM 1 include:

Crittenden et al (2018) Purine metabolism controls innate lymphoid cell function and protects against intestinal injury. Immunol Cell Biol 96 1049 PMID: 29758102

Del Papa et al (2016) The NOTCH1/CD39 axis: a Treg trip-switch for GvHD. Leukemia 30 1931 PMID: 27125307

Fang et al (2016) Expression of CD39 on activated T cells impairs their survival in older individuals. Cell Rep. 14 1218 PMID: 26832412

Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499


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Reviews for POM 1

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POM-1 inhibits PBMCs CD39 activity.
By Anonymous on 02/21/2019
Assay Type: Ex Vivo
Species: Human
Cell Line/Tissue: PBMCs

Human PBMCs were incubated with 10 μM POM-1 for 30 minutes to inhibit CD39 ATPase activity. POM-1 caused a 80% inhibition of PBMCs ATPase activity.

PBMCs were isolated from healthy subjects and from multiple sclerosis patients and CD39 activity was measured by the Malachite Green Phosphate Assay. Cells were washed in phosphate-free buffer and incubated with ATP (250 μM) for 30 minutes at 37ºC. To selectively assess CD39 ATPase activity, POM-1 (10 μM) was added while cells were incubated with ATP.

PMID: 30783191
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.