POM 1

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Cat.No. 2689 - POM 1 | H2O40Na6W12 | CAS No. 12141-67-2
Description: Inhibitor of E-NTPDases
Alternative Names: Sodium polyoxotungstate
Chemical Name: Sodium metatungstate
Datasheet
Citations (5)
Literature

Biological Activity

Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data

M. Wt 2986.01
Formula H2O40Na6W12
Storage Store at RT
CAS Number 12141-67-2
PubChem ID 71311259
InChI Key YVQUUPJGDSQKML-UHFFFAOYSA-N
Smiles O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 298.6 100

Preparing Stock Solutions

The following data is based on the product molecular weight 2986.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.67 mL 3.35 mL
5 mM 0.07 mL 0.33 mL 0.67 mL
10 mM 0.03 mL 0.17 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
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Safety Datasheet

References

References are publications that support the products' biological activity.

Muller et al (2006) Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 16 5943 PMID: 16997558

Grenz et al (2007) Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 21 2863 PMID: 17442731

Wall et al (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. 55 1251 PMID: 18768144


If you know of a relevant reference for POM 1, please let us know.

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Keywords: inhibitors inhibits E-NTPDases ATPases POM1 Sodium polyoxotungstate NTPDase

5 Citations for POM 1

Citations are publications that use Tocris products. Selected citations for POM 1 include:

Del Papa et al (2016) The NOTCH1/CD39 axis: a Treg trip-switch for GvHD. Leukemia 30 1931 PMID: 27125307

Fang et al (2016) Expression of CD39 on activated T cells impairs their survival in older individuals. Cell Rep. 14 1218 PMID: 26832412

Rao et al (2014) A dual role for autophagy in a murine model of lung cancer. Cancer Biol Ther 5 3056 PMID: 24445999

Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499

Yegutkin et al (2012) Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J 26 3875 PMID: 22637533


Do you know of a great paper that uses POM 1 from Tocris? If so please let us know.

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for POM 1

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