PNU 109291

Discontinued Product

PNU 109291 (Cat. No. 2556) has been withdrawn from sale for commercial reasons.
Description: Potent and selective 5-HT1D agonist
Chemical Name: (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for PNU 109291

Potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

Technical Data for PNU 109291

M. Wt 409.52
Formula C24H31N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 187665-60-7
PubChem ID 9909448
Smiles O=C(NC)C3=CC(CCO2)=C(C=C3)[C@@H]2CCN1CCN(C4=CC=C(OC)C=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PNU 109291

Certificate of Analysis / Product Datasheet
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Keywords: PNU 109291, PNU 109291 supplier, Potent, selective, 5-HT1D, agonists, Serotonin, Receptors, PNU109291, 2556, Tocris Bioscience

1 Citation for PNU 109291

Citations are publications that use Tocris products. Selected citations for PNU 109291 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. J Mol Neurosci 3 e00103 PMID: 25692021

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.