PNU 109291

Discontinued Product

PNU 109291 (Cat. No. 2556) has been withdrawn from sale for commercial reasons.
Cat.No. 2556 - PNU 109291 | C24H31N3O3 | CAS No. 187665-60-7
Description: Potent and selective 5-HT1D agonist
Chemical Name: (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

Technical Data

M. Wt 409.52
Formula C24H31N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 187665-60-7
PubChem ID 9909448
InChI Key UDLSEQDYARNKTL-QHCPKHFHSA-N
Smiles O=C(NC)C3=CC(CCO2)=C(C=C3)[C@@H]2CCN1CCN(C4=CC=C(OC)C=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ennis et al (1998) Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J.Med.Chem. 41 2180 PMID: 9632349

Bhattacharya et al (2004) 5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium. J.Pharmacol.Exp.Ther. 309 825 PMID: 14724223

Cutrer et al (1999) Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology 38 1043 PMID: 10428423

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Keywords: PNU 109291, PNU 109291 supplier, Potent, selective, 5-HT1D, agonists, Serotonin, Receptors, PNU109291, 2556, Tocris Bioscience

1 Citation for PNU 109291

Citations are publications that use Tocris products. Selected citations for PNU 109291 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. J Mol Neurosci 3 e00103 PMID: 25692021


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Literature in this Area

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.