Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 681.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.47 mL||7.34 mL||14.67 mL|
|5 mM||0.29 mL||1.47 mL||2.93 mL|
|10 mM||0.15 mL||0.73 mL||1.47 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the products' biological activity.
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Keywords: (+)-Tubocurarine chloride, supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
5 Citations for (+)-Tubocurarine chloride
Citations are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103 PMID: 23576702
Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Biol Chem 31 2937 PMID: 22531784
Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Neurophysiol 285 27067 PMID: 20562108
Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652
Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30 PMID: 25717295
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.