(+)-Tubocurarine chloride

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Cat.No. 2820 - (+)-Tubocurarine chloride | C37H41ClN2O6.HCl | CAS No. 57-94-3
Description: Nicotinic receptor antagonist
Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Technical Data

M. Wt 681.65
Formula C37H41ClN2O6.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 57-94-3
PubChem ID 64645
InChI Key GXFZCDMWGMFGFL-KKXMJGKMSA-N
Smiles OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.82 10
water 17.04 25

Preparing Stock Solutions

The following data is based on the product molecular weight 681.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.34 mL 14.67 mL
5 mM 0.29 mL 1.47 mL 2.93 mL
10 mM 0.15 mL 0.73 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785 PMID:

Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107 PMID:

Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293 PMID:


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Keywords: (+)-Tubocurarine chloride, supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, Nicotinic, Receptors, (Non-selective), Tocris Bioscience

5 Citations for (+)-Tubocurarine chloride

Citations are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:

Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103 PMID: 23576702

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Biol Chem 31 2937 PMID: 22531784

Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Neurophysiol 285 27067 PMID: 20562108

Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652

Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30 PMID: 25717295


Do you know of a great paper that uses (+)-Tubocurarine chloride from Tocris? If so please let us know.

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Literature in this Area

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Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
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  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for (+)-Tubocurarine chloride

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