(+)-Tubocurarine chloride

Pricing Availability   Qty
Description: nAChR antagonist
Chemical Name: 2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride
Purity: ≥98% (HPLC)
Citations (10)
Reviews (1)
Literature (1)

Biological Activity for (+)-Tubocurarine chloride

(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Technical Data for (+)-Tubocurarine chloride

M. Wt 681.65
Formula C37H41ClN2O6.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 57-94-3
PubChem ID 64645
Smiles OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (+)-Tubocurarine chloride

Solvent Max Conc. mg/mL Max Conc. mM
water 17.04 25

Preparing Stock Solutions for (+)-Tubocurarine chloride

The following data is based on the product molecular weight 681.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 5.87 mL 29.34 mL 58.68 mL
1.25 mM 1.17 mL 5.87 mL 11.74 mL
2.5 mM 0.59 mL 2.93 mL 5.87 mL
12.5 mM 0.12 mL 0.59 mL 1.17 mL

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Product Datasheets for (+)-Tubocurarine chloride

Certificate of Analysis / Product Datasheet
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References for (+)-Tubocurarine chloride

References are publications that support the biological activity of the product.

Pederson and Cohen (1990) d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA 87 2785

Peters et al (1990) Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts. 110 107

Wotring and Yoon (1995) The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci. 67 293

If you know of a relevant reference for (+)-Tubocurarine chloride, please let us know.

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Keywords: (+)-Tubocurarine chloride, (+)-Tubocurarine chloride supplier, Nicotinic, receptor, antagonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, curare, (Non-selective), 2820, Tocris Bioscience

10 Citations for (+)-Tubocurarine chloride

Citations are publications that use Tocris products. Selected citations for (+)-Tubocurarine chloride include:

Corns et al (2018) Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nat Commun 9 4015 PMID: 30275467

Pinnock et al (2015) Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. BMC Syst Biol 9 30 PMID: 25717295

Truszkowski et al (2017) A cellular mechanism for inverse effectiveness in multisensory integration. Elife 6 PMID: 28315524

Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816

Nagel et al (2015) Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics. Nat Neurosci 18 56 PMID: 25485755

Zachary and Fuchs (2015) Re-Emergent Inhibition of Cochlear Inner Hair Cells in a Mouse Model of Hearing Loss. J Neurosci 35 9701 PMID: 26134652

Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Front Behav Neurosci 110 103 PMID: 23576702

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Biol Chem 31 2937 PMID: 22531784

Roemmich et al (2018) Ex vivo Whole-cell Recordings in Adult Drosophila Brain. Bio Protoc 8 PMID: 30148187

Lamy et al (2010) Allosteric block of KCa2 channels by apamin. J Neurophysiol 285 27067 PMID: 20562108

Do you know of a great paper that uses (+)-Tubocurarine chloride from Tocris? Please let us know.

Reviews for (+)-Tubocurarine chloride

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Neuromuscular blocking drugs.
By Anonymous on 02/16/2018
Assay Type: In Vivo
Species: Other

We use 2 mg of tubocurarine in a demonstration experiment to review its properties as a neuromuscular blocking drug

To emphasize its action mechanism is useful to compare it with 2 mg of Succinylcholine in a chicken model

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.