(+)-Anabasine hydrochloride

Pricing Availability   Qty
Description: High affinity nAChR partial agonist
Chemical Name: (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for (+)-Anabasine hydrochloride

(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (Ki values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro.

Technical Data for (+)-Anabasine hydrochloride

M. Wt 198.69
Formula C10H14N2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 53912-89-3
PubChem ID 3041330
Smiles [C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (+)-Anabasine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 19.87 100

Preparing Stock Solutions for (+)-Anabasine hydrochloride

The following data is based on the product molecular weight 198.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.03 mL 25.16 mL 50.33 mL
5 mM 1.01 mL 5.03 mL 10.07 mL
10 mM 0.5 mL 2.52 mL 5.03 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets for (+)-Anabasine hydrochloride

References for (+)-Anabasine hydrochloride

References are publications that support the biological activity of the product.

Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967

Parker et al (1998) Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 54 1132 PMID: 9855644

Lu et al (1999) Desensitization of nicotinic agonist-induced [3H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 291 1127 PMID: 10565833

Hong et al (2007) Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 50 351 PMID: 18186309

If you know of a relevant reference for (+)-Anabasine hydrochloride, please let us know.

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Keywords: (+)-Anabasine hydrochloride, (+)-Anabasine hydrochloride supplier, Neuronal, nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, (Non-selective), 1971, Tocris Bioscience

Citations for (+)-Anabasine hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.