(+)-Anabasine hydrochloride

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Cat.No. 1971 - (+)-Anabasine hydrochloride | C10H14N2.HCl | CAS No. 53912-89-3
Description: Neuronal nicotinic receptor partial agonist
Chemical Name: (S)-(+)-3-(2-Piperidinyl)pyridine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity neuronal nicotinic ACh receptor partial agonist (Ki values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca2+-dependent catecholamine release from rat adrenomedullary cells in vitro.

Technical Data

M. Wt 198.69
Formula C10H14N2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 53912-89-3
PubChem ID 3041330
InChI Key VTMZQNZVYCJLGG-PPHPATTJSA-N
Smiles [C@]1([C@H]2NCCCC2)=CC=CN=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.87 100

Preparing Stock Solutions

The following data is based on the product molecular weight 198.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.03 mL 25.16 mL 50.33 mL
5 mM 1.01 mL 5.03 mL 10.07 mL
10 mM 0.5 mL 2.52 mL 5.03 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967

Parker et al (1998) Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 54 1132 PMID: 9855644

Lu et al (1999) Desensitization of nicotinic agonist-induced [3H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 291 1127 PMID: 10565833

Hong et al (2007) Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 50 351 PMID: 18186309


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Keywords: (+)-Anabasine hydrochloride, supplier, Neuronal, nicotinic, receptor, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience

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