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PLpro inhibitor 6 New
SARS-CoV and SAR-CoV-2 PLpro inhibitor (IC50 values are 2.6 and 5.0 μM, respectively). Inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 μM, respectively).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 346.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.89 mL||14.43 mL||28.87 mL|
|5 mM||0.58 mL||2.89 mL||5.77 mL|
|10 mM||0.29 mL||1.44 mL||2.89 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Freitas et al (2020) Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect.Dis. 6 2099 PMID: 32428392
Ratia et al (2008) A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.U.S.A. 105 16119 PMID: 18852458
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