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PLpro inhibitor 19
Biological Activity for PLpro inhibitor 19
PLpro inhibitor 19 is a SARS-CoV-2 inhibitor that inhibits viral replication and PLpro enzymatic activity in vitro (IC50 values are 0.18 μM and 0.44 μM respectively). PLpro inhibitor 19 is selective for PLpro over human deubiquitinating enzymes (DUBs) and DUB-like proteases and displays no cytotoxicity at up to 10 μM.
Technical Data for PLpro inhibitor 19
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PLpro inhibitor 19
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PLpro inhibitor 19
The following data is based on the product molecular weight 531.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.88 mL||9.4 mL||18.81 mL|
|5 mM||0.38 mL||1.88 mL||3.76 mL|
|10 mM||0.19 mL||0.94 mL||1.88 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
Product Datasheets for PLpro inhibitor 19
References for PLpro inhibitor 19
References are publications that support the biological activity of the product.
Shan et al (2021) Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem.Biol. 28 855 PMID: 33979649
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Citations for PLpro inhibitor 19
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