PLpro inhibitor 19

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Cat.No. 7505 - PLpro inhibitor 19 | C31H38FN5O2
Description: SARS-CoV-2 PLpro and replication inhibitor
Chemical Name: (R)-N-(3-Fluoro-5-((1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamido)methyl)phenyl)-4-methylpiperazine-1-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for PLpro inhibitor 19

PLpro inhibitor 19 is a SARS-CoV-2 inhibitor that inhibits viral replication and PLpro enzymatic activity in vitro (IC50 values are 0.18 μM and 0.44 μM respectively). PLpro inhibitor 19 is selective for PLpro over human deubiquitinating enzymes (DUBs) and DUB-like proteases and displays no cytotoxicity at up to 10 μM.

Technical Data for PLpro inhibitor 19

M. Wt 531.68
Formula C31H38FN5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 155925847
InChI Key ZGUISYSWQQIAHK-JOCHJYFZSA-N
Smiles CN1CCN(CC1)C(NC2=CC(F)=CC(CNC(C3CCN(CC3)[C@@H](C4=C5C=CC=CC5=CC=C4)C)=O)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PLpro inhibitor 19

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.17 100
ethanol 53.17 100

Preparing Stock Solutions for PLpro inhibitor 19

The following data is based on the product molecular weight 531.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.4 mL 18.81 mL
5 mM 0.38 mL 1.88 mL 3.76 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for PLpro inhibitor 19

References for PLpro inhibitor 19

References are publications that support the biological activity of the product.

Shan et al (2021) Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem.Biol. 28 855 PMID: 33979649


If you know of a relevant reference for PLpro inhibitor 19, please let us know.

View Related Products by Product Action

View all Papain-like Protease Inhibitors

Keywords: PLpro inhibitor 19, PLpro inhibitor 19 supplier, plproinhibitor19, sarscov2, covid, coronavirus, enzymes, inhibitors, papain, like, proteases, viral, virus, replication, Papain-like, Proteases, Coronavirus, 7505, Tocris Bioscience

Citations for PLpro inhibitor 19

Citations are publications that use Tocris products.

Currently there are no citations for PLpro inhibitor 19. Do you know of a great paper that uses PLpro inhibitor 19 from Tocris? Please let us know.

Reviews for PLpro inhibitor 19

There are currently no reviews for this product. Be the first to review PLpro inhibitor 19 and earn rewards!

Have you used PLpro inhibitor 19?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation