PLP (139-151)

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Cat.No. 2567 - PLP (139-151) | His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe | CAS No. 122018-58-0
Description: Encephalitogenic myelin proteolipid fragment
Alternative Names: Proteolipid protein (139-151)
Datasheet
Citations (3)
Literature

Biological Activity

Synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.

Technical Data

M. Wt 1521.74
Formula C72H104N20O17
Sequence HSLGKWLGHPDKF
Storage Desiccate at -20°C
CAS Number 122018-58-0
PubChem ID 16199055
InChI Key UQIBUOXNUPHALR-UVIWMAFZSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1521.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.66 mL 3.29 mL 6.57 mL
5 mM 0.13 mL 0.66 mL 1.31 mL
10 mM 0.07 mL 0.33 mL 0.66 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343

Sobel et al (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 49 468 PMID: 2273404

Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 59 305 PMID: 1716908


If you know of a relevant reference for PLP (139-151), please let us know.

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Keywords: PLP (139-151), supplier, Encephalitogenic, myelin, proteolipid, fragment, Neuronal, Metabolism, multiple, sclerosis, encephalomyelitis, EAE, Proteolipid, protein, (139-151), Neuronal, Metabolism, Tocris Bioscience

3 Citations for PLP (139-151)

Citations are publications that use Tocris products. Selected citations for PLP (139-151) include:

Arima et al (2015) A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model. Elife 4 PMID: 26193120

Jana et al (2012) Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β. J Biol Chem 287 34134 PMID: 22879602

Mondal et al (2012) Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis. J Clin Cell Immunol 3 124 PMID: 23275862


Do you know of a great paper that uses PLP (139-151) from Tocris? If so please let us know.

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for PLP (139-151)

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