PL 017

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Cat.No. 2024 - PL 017 | Tyr-Pro-N-Methyl-Phe-D-Pro-NH2 | CAS No. 83397-56-2
Description: Selective μ agonist
Datasheet
Citations
Literature

Biological Activity

Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.

Technical Data

M. Wt 535.64
Formula C29H37N5O5
Sequence YPFP

(Modifications:Phe-3 = N-methyl-Phe, Pro-4 = C-terminal amide)

Storage Store at -20°C
CAS Number 83397-56-2
PubChem ID 10437173
InChI Key JAKBYSTWCHUQOK-QORCZRPOSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 535.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.87 mL 9.33 mL 18.67 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
10 mM 0.19 mL 0.93 mL 1.87 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chang et al (1983) Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J.Pharmacol.Exp.Ther. 227 403 PMID: 6313901

Meyer and Meyer (1993) Behavioral effects of the μ-opioid peptide agonists DAMGO, DALDA and PL017 on locomotor activities. Pharmacol.Biochem.Behav. 46 391 PMID: 8265694

Xin et al (1997) Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J.Pharmacol.Exp.Ther. 281 499 PMID: 9103537


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Keywords: PL 017, supplier, mu, m, opioid, agonists, analgesia, catalepsy, hyperthermia, PL017, potent, selective, Mu, Opioid, Receptors, Mu, Opioid, Receptors, Tocris Bioscience

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