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Submit ReviewPL 017
Discontinued Product
2024 has been discontinued.
Description: Selective μ agonist
Biological Activity for PL 017
Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.
Technical Data for PL 017
| M. Wt | 535.64 |
| Formula | C29H37N5O5 |
| Sequence |
YPFP (Modifications:Phe-3 = N-methyl-Phe, Pro-4 = D-Pro & C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 83397-56-2 |
| PubChem ID | 10437173 |
| InChI Key | JAKBYSTWCHUQOK-QORCZRPOSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PL 017
References for PL 017
References are publications that support the biological activity of the product.
Chang et al (1983) Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J.Pharmacol.Exp.Ther. 227 403 PMID: 6313901
Meyer and Meyer (1993) Behavioral effects of the μ-opioid peptide agonists DAMGO, DALDA and PL017 on locomotor activities. Pharmacol.Biochem.Behav. 46 391 PMID: 8265694
Xin et al (1997) Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain. J.Pharmacol.Exp.Ther. 281 499 PMID: 9103537
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Keywords: PL 017, PL 017 supplier, mu, m, opioid, agonists, analgesia, catalepsy, hyperthermia, PL017, potent, selective, Mu, Opioid, Receptors, 2024, Tocris Bioscience
Citations for PL 017
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Currently there are no citations for PL 017.
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