PKI 166 hydrochloride
Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO and to 50 mM in ethanol|
References are publications that support the biological activity of the product.
Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID: 10850439
Ulu et al (2013) Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats. J.Pharmacol.Exp.Ther. 345 393 PMID: 23528611
Kaspersen et al (2012) Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena. Bioorg.Chem. 44 35 PMID: 22832269
If you know of a relevant reference for PKI 166 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PKI 166 hydrochloride, PKI 166 hydrochloride supplier, 187724-61-4, potent, EGFR, kinase, inhibitors, epidermal, growth, factor, receptor, tyrosine, antiangiogenic, antitumor, antitumour, inhibits, PKI166, 4941, Tocris Bioscience
Citations for PKI 166 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for PKI 166 hydrochloride. Do you know of a great paper that uses PKI 166 hydrochloride from Tocris? Please let us know.
Reviews for PKI 166 hydrochloride
There are currently no reviews for this product. Be the first to review PKI 166 hydrochloride and earn rewards!
Have you used PKI 166 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.