PKC fragment (530-558)

Discontinued Product

Unfortunately PKC fragment (530-558) (Cat. No. 1887) has been withdrawn from sale for commercial reasons.
Cat.No. 1887 - PKC Fragment (530-558) | Leu-Leu-Tyr-Glu-Met-Leu-Ala-Gly-Gln-Ala-Pro-Phe-Glu-Gly-Glu-Asp-Glu-Asp-Glu-Leu-Phe-Gln-Ser-Ile-Met-Glu-His-Asn-Val-NH2 | CAS No. 122613-29-0
Description: Potent activator of protein kinase C
Datasheet
Citations
Literature

Biological Activity

Potent activator of protein kinase C (Ka ~ 10 mM); corresponds to residues 530-558 of the catalytic domain of PKC.

Technical Data

M. Wt 3354.7
Formula C148H221N35O50S2
Sequence LLYEMLAGQAPFEGEDEDELFQSIMEHNV

(Modifications: Val-29 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 122613-29-0
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 3354.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.3 mL 1.49 mL 2.98 mL
5 mM 0.06 mL 0.3 mL 0.6 mL
10 mM 0.03 mL 0.15 mL 0.3 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

House et al (1989) A synthetic peptide analog of the putative substrate-binding motif activates protein kinase C. FEBS Lett. 249 243 PMID: 2737283

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Keywords: Potent activators protein kinases C PKC Protein Protein Kinase C

Citations for PKC fragment (530-558)

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Pathways for PKC fragment (530-558)

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