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Submit ReviewPKC β pseudosubstrate
Description: Selective cell-permeable PKC inhibitor peptide (attached to vector)
Alternative Names: Protein kinase C beta pseudosubstrate
Biological Activity for PKC β pseudosubstrate
PKC β pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.
Technical Data for PKC β pseudosubstrate
| M. Wt | 3994.84 |
| Formula | C177H294N62O38S3 |
| Sequence |
CRQIKIWFQNRRMKWKK CRFARKGALRQKNV* (Modifications: Disulfide bridge between 17 -1*) |
| Storage | Store at -20°C |
| CAS Number | 172308-76-8 |
| PubChem ID | 90488712 |
| InChI Key | KIWJPYSSLFMLBZ-OSCDWKIESA-N |
| Smiles | [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PKC β pseudosubstrate
References for PKC β pseudosubstrate
References are publications that support the biological activity of the product.
Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444 PMID: 8144628
House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID: 3686012
Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470
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Keywords: PKC b pseudosubstrate, PKC b pseudosubstrate supplier, Selective, cell-permeable, PKC, inhibitors, inhibits, Protein, Kinases, C, beta, pseudosubstrate, PKCb, kinase, Kinase, 1792, Tocris Bioscience
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