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PKC β pseudosubstrate

Cat. No. 1792 Submit a Review Datasheet / COA / SDS

Discontinued Product

PKC β pseudosubstrate (Cat. No. 1792) has been withdrawn from sale for commercial reasons.
Description: Selective cell-permeable PKC inhibitor peptide (attached to vector)
Alternative Names: Protein kinase C beta pseudosubstrate
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Datasheets References

Biological Activity for PKC β pseudosubstrate

PKC β pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM). Consists of amino acids 19 - 31 of PKC pseudosubstrate domain linked by a disulphide bridge to a cell permeabilisation Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide.

Technical Data for PKC β pseudosubstrate

M. Wt 3994.84
Formula C177H294N62O38S3
Sequence CRQIKIWFQNRRMKWKK CRFARKGALRQKNV*

(Modifications: Disulfide bridge between 17 -1*)
Storage Store at -20°C
CAS Number 172308-76-8
PubChem ID 90488712
InChI Key KIWJPYSSLFMLBZ-OSCDWKIESA-N
Smiles [H]N[C@@H](CSSC[C@H](N[H])C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PKC β pseudosubstrate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PKC β pseudosubstrate

References are publications that support the biological activity of the product.

Derossi et al (1994) The third helix of the antennapedia homeodomain translocates through biological membranes. J.Biol.Chem. 269 10444 PMID: 8144628

House and Kemp (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 1726 PMID: 3686012

Theodore et al (1995) Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J.Neurosci. 15 7158 PMID: 7472470

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Keywords: PKC b pseudosubstrate, PKC b pseudosubstrate supplier, Selective, cell-permeable, PKC, inhibitors, inhibits, Protein, Kinases, C, beta, pseudosubstrate, PKCb, kinase, Kinase, 1792, Tocris Bioscience

Citations for PKC β pseudosubstrate

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