PKC 412

Cat. No. 2992 5 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

PKC 412 (Cat. No. 2992) has been withdrawn from sale for commercial reasons.

Description: Protein kinase C inhibitor

Alternative Names: CGP 41251

Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Literature (1)

Biological Activity Technical Data Datasheets References

Biological Activity for PKC 412

PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1, EGFR and MARK (microtubule affinity regulating kinase). Displays potent antitumor activity. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Technical Data for PKC 412

M. Wt	570.64
Formula	C₃₅H₃₀N₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	120685-11-2
PubChem ID	9829523
InChI Key	BMGQWWVMWDBQGC-IIFHNQTCSA-N
Smiles	O=C(NC6)C1=C6C4=C3C2=C1C8=C(C=CC=C8)N2[C@](C[C@@H](N(C(C9=CC=CC=C9)=O)C)[C@H]7OC)([H])O[C@]7(C)N3C5=CC=CC=C45

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PKC 412

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for PKC 412

References are publications that support the biological activity of the product.

Fabbro et al (2000) PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 15 17 PMID: 10888033

Tenzer et al (2001) The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 61 8203 PMID: 11719451

Nakazono-Kusaba et al (2004) PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Eur.J.Pharmacol. 497 155 PMID: 15306200

Gordon et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859

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