PKC (19-36)

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Cat.No. 4058 - PKC (19-36) | Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-His-Glu-Val-Lys-Asn | CAS No. 113731-96-7
Description: Pseudosubstrate peptide; inhibitor of PKC
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Pseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 μM). Attenuates vascular hyperproliferation and hypertrophy induced by high glucose. Inhibits DNA and protein synthesis in vascular smooth muscle cells (VSMCs) in a dose-dependent manner.

Negative Control also available.

Technical Data

M. Wt 2151.48
Formula C93H159N35O24
Sequence RFARKGALRQKNVHEVKN
Storage Store at -20°C
CAS Number 113731-96-7
PubChem ID 71308428
InChI Key NHCJMYZDRROLEW-OFXZVSIYSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Yasunari et al (1996) Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration Hypertension 28 159 PMID: 8707376


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Keywords: PKC (19-36), PKC (19-36) supplier, PKC, inhibitors, inhibits, pseudosubstrate, protein, kinase, C, fragment, (19-36), PKCI, Protein, Kinase, 4058, Tocris Bioscience

1 Citation for PKC (19-36)

Citations are publications that use Tocris products. Selected citations for PKC (19-36) include:

Glovaci and Chapman (2015) Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex. Mol Med Rep 10 e0131948 PMID: 26133167


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