PK 44 phosphate

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Cat.No. 4145 - PK 44 phosphate | C17H16F5N7O.H3PO4 | CAS No. 1017682-66-4
Description: Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
Purity: ≥98% (HPLC)

Biological Activity for PK 44 phosphate

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Compound Libraries for PK 44 phosphate

PK 44 phosphate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PK 44 phosphate

M. Wt 527.34
Formula C17H16F5N7O.H3PO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1017682-66-4
PubChem ID 90488917
Smiles N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PK 44 phosphate

Solvent Max Conc. mg/mL Max Conc. mM
water 52.73 100
DMSO 52.73 100

Preparing Stock Solutions for PK 44 phosphate

The following data is based on the product molecular weight 527.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for PK 44 phosphate

References for PK 44 phosphate

References are publications that support the biological activity of the product.

Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52

If you know of a relevant reference for PK 44 phosphate, please let us know.

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Citations for PK 44 phosphate

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