PK 44 phosphate

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Cat.No. 4145 - PK 44 phosphate | C17H16F5N7O.H3PO4 | CAS No. 1017682-66-4
Description: Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Compound Libraries

PK 44 phosphate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 527.34
Formula C17H16F5N7O.H3PO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1017682-66-4
PubChem ID 90488917
InChI Key IRIGBESJZBGJOS-DDWIOCJRSA-N
Smiles N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.73 100
water 52.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 527.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52 PMID:


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Citations for PK 44 phosphate

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