PK 11195

Pricing Availability   Qty
Cat.No. 0670 - PK 11195 | C21H21ClN2O | CAS No. 85532-75-8
Description: Antagonist at peripheral benzodiazepine receptors
Chemical Name: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (2)

Biological Activity

Possesses high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR).

Compound Libraries

PK 11195 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 352.86
Formula C21H21ClN2O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85532-75-8
PubChem ID 1345
InChI Key RAVIZVQZGXBOQO-UHFFFAOYSA-N
Smiles CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 17.64 50
DMSO 17.64 50

Preparing Stock Solutions

The following data is based on the product molecular weight 352.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.67 mL 28.34 mL 56.68 mL
2.5 mM 1.13 mL 5.67 mL 11.34 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
25 mM 0.11 mL 0.57 mL 1.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

View Related Products by Product Action

View all Translocator Protein Ligands

Keywords: PK 11195, PK 11195 supplier, antagonists, peripheral, benzodiazepine, receptors, GABAA, Receptors, PK11195, PBR, TSPO, Constitutive, Androstane, Receptor, Translocator, Protein, 0670, Tocris Bioscience

3 Citations for PK 11195

Citations are publications that use Tocris products. Selected citations for PK 11195 include:

Gut et al (2013) Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. J Cell Mol Med 9 97 PMID: 23201900

Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Nat Chem Biol 89 564 PMID: 12888831

Anderson et al (2011) Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett 202 148 PMID: 21315811


Do you know of a great paper that uses PK 11195 from Tocris? Please let us know.

Reviews for PK 11195

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used PK 11195?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


A peripheral benzodiazepine receptor (PBR) agonist..
By Anonymous on 05/02/2018
Assay Type: In Vitro
Species: Human

It is a peripheral benzodiazepine receptor (PBR) agonist. It is effective in inhibiting LPS-induced pro-inflammatory cytokines such as IL-1beta and TNF-alpha in microglia culture.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease