PK 11195

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Cat.No. 0670 - PK 11195 | C21H21ClN2O | CAS No. 85532-75-8
Description: Antagonist at peripheral benzodiazepine receptors
Chemical Name: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Citations (3)
Reviews (1)
Literature (2)

Biological Activity for PK 11195

Possesses high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR).

Compound Libraries for PK 11195

PK 11195 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PK 11195

M. Wt 352.86
Formula C21H21ClN2O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85532-75-8
PubChem ID 1345
Smiles CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PK 11195

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 17.64 50
DMSO 17.64 50

Preparing Stock Solutions for PK 11195

The following data is based on the product molecular weight 352.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.67 mL 28.34 mL 56.68 mL
2.5 mM 1.13 mL 5.67 mL 11.34 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
25 mM 0.11 mL 0.57 mL 1.13 mL

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Product Datasheets for PK 11195

Certificate of Analysis / Product Datasheet
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Keywords: PK 11195, PK 11195 supplier, antagonists, peripheral, benzodiazepine, receptors, GABAA, Receptors, PK11195, PBR, TSPO, Constitutive, Androstane, Receptor, Translocator, Protein, 0670, Tocris Bioscience

3 Citations for PK 11195

Citations are publications that use Tocris products. Selected citations for PK 11195 include:

Sutter et al (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Nat Chem Biol 89 564 PMID: 12888831

Anderson et al (2011) Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett 202 148 PMID: 21315811

Gut et al (2013) Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. J Cell Mol Med 9 97 PMID: 23201900

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Reviews for PK 11195

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A peripheral benzodiazepine receptor (PBR) agonist..
By Anonymous on 05/02/2018
Assay Type: In Vitro
Species: Human

It is a peripheral benzodiazepine receptor (PBR) agonist. It is effective in inhibiting LPS-induced pro-inflammatory cytokines such as IL-1beta and TNF-alpha in microglia culture.

Literature in this Area

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