Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPurinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
M. Wt | 396.42 |
Formula | C13H8N2O2.C7H8O3S |
Storage | Desiccate at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 56583-49-4 |
PubChem ID | 124333 |
InChI Key | MMPTYEXNPWSTOR-UHFFFAOYSA-N |
Smiles | CC1=CC=C(C=C1)S(O)(=O)=O.[O-][N+]1=C(C(=O)C2=CC=CC=C12)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
ethanol | 5.95 | 15 with gentle warming | |
DMSO | 31.71 | 80 |
The following data is based on the product molecular weight 396.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.8 mM | 3.15 mL | 15.77 mL | 31.53 mL |
4 mM | 0.63 mL | 3.15 mL | 6.31 mL |
8 mM | 0.32 mL | 1.58 mL | 3.15 mL |
40 mM | 0.06 mL | 0.32 mL | 0.63 mL |
References are publications that support the biological activity of the product.
King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br.J.Pharmacol. 117 1111 PMID: 8882604
Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530 PMID: 9031760
Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575 PMID: 1148500
If you know of a relevant reference for PIT, please let us know.
Keywords: PIT, PIT supplier, P2Y, ligands, displays, mixed, antagonism/potentiation, Receptors, Purinergic, antagonists, potentiators, purinoceptors, 2,2'-Pyridylisatogen, tosylate, 1682, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for PIT. Do you know of a great paper that uses PIT from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review PIT and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image