PIT
Biological Activity
Purinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
Technical Data
| M. Wt | 396.42 |
| Formula | C13H8N2O2.C7H8O3S |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 56583-49-4 |
| PubChem ID | 124333 |
| InChI Key | MMPTYEXNPWSTOR-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C=C1)S(O)(=O)=O.[O-][N+]1=C(C(=O)C2=CC=CC=C12)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 5.95 | 15 with gentle warming | |
| DMSO | 31.71 | 80 |
Preparing Stock Solutions
The following data is based on the product molecular weight 396.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.8 mM | 3.15 mL | 15.77 mL | 31.53 mL |
| 4 mM | 0.63 mL | 3.15 mL | 6.31 mL |
| 8 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 40 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br.J.Pharmacol. 117 1111 PMID: 8882604
Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530 PMID: 9031760
Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575 PMID: 1148500
If you know of a relevant reference for PIT, please let us know.
View Related Products by Target
Keywords: PIT, PIT supplier, P2Y, ligands, displays, mixed, antagonism/potentiation, Receptors, Purinergic, antagonists, potentiators, purinoceptors, 2,2'-Pyridylisatogen, tosylate, 1682, Tocris Bioscience
Citations for PIT
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Pain Research Product Guide
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.
Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
