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Description: P2Y ligand; displays mixed antagonism/potentiation
Alternative Names: 2,2'-Pyridylisatogen tosylate
Chemical Name: 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate
Purity: ≥99% (HPLC)
Biological Activity
Purinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
Technical Data
| M. Wt | 396.42 |
| Formula | C13H8N2O2.C7H8O3S |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 56583-49-4 |
| PubChem ID | 124333 |
| InChI Key | MMPTYEXNPWSTOR-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C=C1)S(O)(=O)=O.[O-][N+]1=C(C(=O)C2=CC=CC=C12)C1=CC=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 5.95 | 15 with gentle warming | |
| DMSO | 31.71 | 80 |
Preparing Stock Solutions
The following data is based on the product molecular weight 396.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.8 mM | 3.15 mL | 15.77 mL | 31.53 mL |
| 4 mM | 0.63 mL | 3.15 mL | 6.31 mL |
| 8 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 40 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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References
References are publications that support the biological activity of the product.
King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br.J.Pharmacol. 117 1111 PMID: 8882604
Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530 PMID: 9031760
Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575 PMID: 1148500
If you know of a relevant reference for PIT, please let us know.
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Keywords: PIT, PIT supplier, P2Y, ligands, displays, mixed, antagonism/potentiation, Receptors, Purinergic, antagonists, potentiators, purinoceptors, 2,2'-Pyridylisatogen, tosylate, 1682, Tocris Bioscience
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