Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||6.35||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 317.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.15 mL||15.76 mL||31.51 mL|
|5 mM||0.63 mL||3.15 mL||6.3 mL|
|10 mM||0.32 mL||1.58 mL||3.15 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Raj et al (2011) Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475 231 PMID: 21753854
Golovine et al (2012) Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells. Prostate [Epub ahead of print] PMID: 22592999
If you know of a relevant reference for Piperlongumine, please let us know.
View Related Products by Target
Keywords: Piperlongumine, supplier, antitumor, selectively, cytotoxic, increases, induces, ros, reactive, oxygen, species, cancer, cells, piperlongumine, supplier, androgen, receptor, p53, proapoptotic, p53, Apoptosis, Inducers, Androgen, Receptor, Apoptosis, Inducers, Tocris Bioscience
1 Citation for Piperlongumine
Citations are publications that use Tocris products. Selected citations for Piperlongumine include:
Farrand et al (2013) An improved quantitative approach for the assessment of mitochondrial fragmentation in chemoresistant ovarian cancer cells. PLoS One 8 e74008 PMID: 24040144
Do you know of a great paper that uses Piperlongumine from Tocris? If so please let us know.
Literature in this Area
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.