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Submit ReviewK+ channel opener and vasodilator. Activates KATP channels (IC50 for relaxation of coronary arteries = 1.26 μM). Clinically used antihypertensive agent.
M. Wt | 245.33 |
Formula | C13H19N5 |
Storage | Store at RT |
Purity | ≥98% (HPLC) |
CAS Number | 60560-33-0 |
Smiles | CC(N\C(NC1=CC=NC=C1)=N/C#N)C(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Gollasch et al (1995) Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J.Pharmacol.Exp.Ther. 275 681 PMID: 7473155
Kimura et al (1988) Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats. J.Pharmacobiodyn. 11 430 PMID: 3171884
Petersen (1978) Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. J.Med.Chem. 21 773 PMID: 691003
View all Inward Rectifier Potassium (Kir) Channel Activators
Keywords: Pinacidil, Pinacidil supplier, Inward, rectifier, Potassium, Channels, 1503, Tocris Bioscience
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