Pinacidil

Discontinued Product

Unfortunately Pinacidil (Cat. No. 1503) has been withdrawn from sale for commercial reasons.
Cat.No. 1503 - Pinacidil | C13H19N5 | CAS No. 60560-33-0
Description: K+ channel opener. Activates KATP channels
Chemical Name: N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

K+ channel opener and vasodilator. Activates KATP channels (IC50 for relaxation of coronary arteries = 1.26 μM). Clinically used antihypertensive agent.

Technical Data

M. Wt 245.33
Formula C13H19N5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 60560-33-0
Smiles CC(N\C(NC1=CC=NC=C1)=N/C#N)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 245.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.08 mL 20.38 mL 40.76 mL
5 mM 0.82 mL 4.08 mL 8.15 mL
10 mM 0.41 mL 2.04 mL 4.08 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gollasch et al (1995) Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J.Pharmacol.Exp.Ther. 275 681 PMID: 7473155

Kimura et al (1988) Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats. J.Pharmacobiodyn. 11 430 PMID: 3171884

Petersen (1978) Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. J.Med.Chem. 21 773 PMID: 691003

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Citations for Pinacidil

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Literature in this Area

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