Discontinued Product

Pinacidil (Cat. No. 1503) has been withdrawn from sale for commercial reasons.
Description: K+ channel opener. Activates KATP channels
Chemical Name: N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine
Purity: ≥98% (HPLC)

Biological Activity for Pinacidil

K+ channel opener and vasodilator. Activates KATP channels (IC50 for relaxation of coronary arteries = 1.26 μM). Clinically used antihypertensive agent.

Technical Data for Pinacidil

M. Wt 245.33
Formula C13H19N5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 60560-33-0
Smiles CC(N\C(NC1=CC=NC=C1)=N/C#N)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Pinacidil

Certificate of Analysis / Product Datasheet
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References for Pinacidil

References are publications that support the biological activity of the product.

Gollasch et al (1995) Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J.Pharmacol.Exp.Ther. 275 681 PMID: 7473155

Kimura et al (1988) Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats. J.Pharmacobiodyn. 11 430 PMID: 3171884

Petersen (1978) Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. J.Med.Chem. 21 773 PMID: 691003

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Keywords: Pinacidil, Pinacidil supplier, Inward, rectifier, Potassium, Channels, 1503, Tocris Bioscience

Citations for Pinacidil

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