Discontinued ProductUnfortunately Pinacidil (Cat. No. 1503) has been withdrawn from sale for commercial reasons.
K+ channel opener and vasodilator. Activates KATP channels (IC50 for relaxation of coronary arteries = 1.26 μM). Clinically used antihypertensive agent.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 245.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.08 mL||20.38 mL||40.76 mL|
|5 mM||0.82 mL||4.08 mL||8.15 mL|
|10 mM||0.41 mL||2.04 mL||4.08 mL|
|50 mM||0.08 mL||0.41 mL||0.82 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Gollasch et al (1995) Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J.Pharmacol.Exp.Ther. 275 681 PMID: 7473155
Kimura et al (1988) Effects of an antihypertensive vasodilator, pinacidil, on regional blood flow in conscious spontaneously hypertensive rats. J.Pharmacobiodyn. 11 430 PMID: 3171884
Petersen (1978) Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. J.Med.Chem. 21 773 PMID: 691003
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Keywords: Inward rectifier Potassium Channels
Citations for Pinacidil
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Currently there are no citations for Pinacidil.