PHM 27 (human)

Pricing Availability Delivery Time Qty
Cat.No. 2080 - PHM 27 (human) | His-Ala-Asp-Gly-Val-Phe-Thr-Ser-Asp-Phe-Ser-Lys-Leu-Leu-Gly-Gln-Leu-Ser-Ala-Lys-Lys-Tyr-Leu-Glu-Ser-Leu-Met-NH2 | CAS No. 118025-43-7
Description: Potent calcitonin receptor agonist; endogenous analog of human VIP
Alternative Names: Peptide histidine methionine 27 (human), Human PHI 27
Datasheet
Citations
Literature

Biological Activity

Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.

Technical Data

M. Wt 2985.44
Formula C135H214N34O40S
Sequence HADGVFTSDFSKLLGQLSAKKYLESLM

(Modifications: Met-27 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 118025-43-7
PubChem ID 16133840
InChI Key YLBIOQUUAYXLJJ-WZUUGAJWSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 5% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 2985.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.67 mL 3.35 mL
5 mM 0.07 mL 0.33 mL 0.67 mL
10 mM 0.03 mL 0.17 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547 PMID: 6571696

Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269 21223 PMID: 8063743

Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279 PMID: 15013843


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