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PhiKan 083

Cat. No. 4326 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: p53 stabilizing agent
Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PhiKan 083

PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Compound Libraries for PhiKan 083

PhiKan 083 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PhiKan 083

M. Wt 274.79
Formula C16H18N2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1050480-30-2
PubChem ID 16255105
InChI Key IXWVUPURFWFRNE-UHFFFAOYSA-N
Smiles CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PhiKan 083

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.74 50
DMSO 27.48 100

Preparing Stock Solutions for PhiKan 083

The following data is based on the product molecular weight 274.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.64 mL 18.2 mL 36.39 mL
5 mM 0.73 mL 3.64 mL 7.28 mL
10 mM 0.36 mL 1.82 mL 3.64 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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References for PhiKan 083

References are publications that support the biological activity of the product.

Boeckler et al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360 PMID: 18650397

Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245 PMID: 20498645

If you know of a relevant reference for PhiKan 083, please let us know.

View Related Products by Target

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1 Citation for PhiKan 083

Citations are publications that use Tocris products. Selected citations for PhiKan 083 include:

Soares et al (2016) Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget 7 4326 PMID: 26735173

Do you know of a great paper that uses PhiKan 083 from Tocris? Please let us know.

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Literature in this Area

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Cancer Research Product Guide

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Cell Cycle and DNA Damage Research Product Guide

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Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PhiKan 083

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.