PhiKan 083

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Cat.No. 4326 - PhiKan 083 | C16H18N2.HCl | CAS No. 880813-36-5
Description: p53 stabilizing agent
Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.

Compound Libraries

PhiKan 083 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 274.79
Formula C16H18N2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 880813-36-5
PubChem ID 16255105
InChI Key IXWVUPURFWFRNE-UHFFFAOYSA-N
Smiles CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.48 100
ethanol 13.74 50
water 13.74 50

Preparing Stock Solutions

The following data is based on the product molecular weight 274.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.64 mL 18.2 mL 36.39 mL
5 mM 0.73 mL 3.64 mL 7.28 mL
10 mM 0.36 mL 1.82 mL 3.64 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Boeckler et al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360 PMID: 18650397

Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245 PMID: 20498645


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Keywords: PhiKan083 supplier p53 stabilizing stabilising stabiliser agent transcription factors Y220C mutation thermostability p53

Citations for PhiKan 083

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PhiKan 083

p53

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.

Protocols

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