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Biological Activity for PhiKan 083
PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.
Compound Libraries for PhiKan 083
Technical Data for PhiKan 083
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PhiKan 083
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PhiKan 083
The following data is based on the product molecular weight 274.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.64 mL||18.2 mL||36.39 mL|
|5 mM||0.73 mL||3.64 mL||7.28 mL|
|10 mM||0.36 mL||1.82 mL||3.64 mL|
|50 mM||0.07 mL||0.36 mL||0.73 mL|
References for PhiKan 083
References are publications that support the biological activity of the product.
Boeckler et al (2008) Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 105 10360 PMID: 18650397
Wiman (2010) Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 29 4245 PMID: 20498645
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1 Citation for PhiKan 083
Citations are publications that use Tocris products. Selected citations for PhiKan 083 include:
Soares et al (2016) Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget 7 4326 PMID: 26735173
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Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair PosterUpdated
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.