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Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.
(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH))
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193 PMID: 2907489
Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729 PMID: 12489786
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
If you know of a relevant reference for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin, please let us know.
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Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, [Phe8Y(CH-NH)Arg9]-Bradykinin supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin, 3229, Tocris Bioscience
1 Citation for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin
Citations are publications that use Tocris products. Selected citations for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin include:
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
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