[Phe8Ψ(CH-NH)-Arg9]-Bradykinin

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Cat.No. 3229 - [Phe8Y(CH-NH)Arg9]-Bradykinin | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Ψ(CH2-NH)-Arg | CAS No. 118122-39-7
Description: Selective B2 agonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action than bradykinin (Cat No. 3004) in vivo.

Technical Data

M. Wt 1046.23
Formula C50H75N15O10
Sequence RPPGFSPFR

(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH))

Storage Desiccate at -20°C
CAS Number 118122-39-7
PubChem ID 3082903
InChI Key XKJBISGEHGXKBF-TZPCGENMSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](CN[C@@H](CCCNC(N)=N)C(O)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Drapeau et al (1988) [Phe8Ψ(CH2-NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or kininase II. Eur.J.Pharmacol. 155 193 PMID: 2907489

Marceau et al (2002) Kinin receptors: functional aspects. Int.Immunopharmacol. 2 1729 PMID: 12489786

Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727


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View all Bradykinin Receptor Agonists

Keywords: [Phe8Y(CH-NH)Arg9]-Bradykinin, [Phe8Y(CH-NH)Arg9]-Bradykinin supplier, Selective, B2, agonists, Bradykinin, Receptors, [Phe8psi(CH-NH)Arg9]-Bradykinin, 3229, Tocris Bioscience

1 Citation for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin

Citations are publications that use Tocris products. Selected citations for [Phe8Ψ(CH-NH)-Arg9]-Bradykinin include:

Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324


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