Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
Description: Selective nociceptin receptor agonist
Biological Activity
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 is a potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).
Technical Data
| M. Wt | 1367.6 |
| Formula | C61H102N22O14 |
| Sequence |
FGGFTGARKSARK (Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH2-NH), Lys-13 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 213130-17-7 |
| PubChem ID | 6324602 |
| InChI Key | ZHKMSRDIVOXQKP-YILJZHMHSA-N |
| Smiles | [H]N[C@H](CNCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
References
References are publications that support the biological activity of the product.
Guerrini et al (1997) Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 40 1789 PMID: 9191955
Guerrini et al (1998) A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 123 163 PMID: 9489602
Okawa et al (1999) Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 127 123 PMID: 10369464
Xu et al (1998) [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 249 127 PMID: 9682833
View Related Products by Target
View Related Products by Product Action
Keywords: [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2 supplier, Selective, nociceptin, agonists, Receptors, ORL1, OP4, NOP, Opioid, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, 1092, Tocris Bioscience
1 Citation for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
Citations are publications that use Tocris products. Selected citations for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 include:
McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. J Biol Chem 132 1175 PMID: 11250866
Reviews for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
There are currently no reviews for this product. Be the first to review [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 and earn rewards!
Have you used [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.