Home / Pharmacology / 7-TM Receptors / Opioid Receptors / NOP Receptors / NOP Receptor Agonists / [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2

[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2

Cat. No. 1092 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 1092 - [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2 | Phe(Ψ(CH2-NH))-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2 | CAS No. 213130-17-7
Description: Selective nociceptin receptor agonist
Datasheet
Citations (1)
Reviews
Literature (5)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).

Technical Data

M. Wt 1367.6
Formula C61H102N22O14
Sequence FGGFTGARKSARK

(Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH2-NH), Lys-13 = C-terminal amide)
Storage Desiccate at -20°C
CAS Number 213130-17-7
PubChem ID 6324602
InChI Key ZHKMSRDIVOXQKP-YILJZHMHSA-N
Smiles [H]N[C@H](CNCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 0.70 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the biological activity of the product.

Guerrini et al (1997) Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 40 1789 PMID: 9191955

Guerrini et al (1998) A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 123 163 PMID: 9489602

Okawa et al (1999) Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 127 123 PMID: 10369464

Xu et al (1998) [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 249 127 PMID: 9682833

If you know of a relevant reference for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NOP Receptor Agonists

Keywords: [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2 supplier, Selective, nociceptin, agonists, Receptors, ORL1, OP4, NOP, Opioid, [Phe1Psi(CH2-NH)Gly2]Nociceptin(1-13)NH2, 1092, Tocris Bioscience

1 Citation for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2

Citations are publications that use Tocris products. Selected citations for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 include:

McLeod et al (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. J Biol Chem 132 1175 PMID: 11250866

Do you know of a great paper that uses [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 from Tocris? Please let us know.

Reviews for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2

There are currently no reviews for this product. Be the first to review [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 and earn rewards!

Have you used [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.