PHA 767491 hydrochloride

Cat. No. 3140 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

Chemical Name: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride

Purity: ≥99% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for PHA 767491 hydrochloride

PHA 767491 hydrochloride is an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 0.034 - 0.75, 0.24 - 1.2, 0.25 - 1.1 and 0.46 - 1 μM for cdk9, cdk2, cdk1 and cdk5, respectively). Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2; IC₅₀ = 171 nM). Prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo.

Compound Libraries for PHA 767491 hydrochloride

PHA 767491 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PHA 767491 hydrochloride

M. Wt	249.7
Formula	C₁₂H₁₁N₃O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	942425-68-5
PubChem ID	11715766
InChI Key	IMVNFURYBZMFDZ-UHFFFAOYSA-N
Smiles	O=C1NCCC2=C1C=C(C3=CC=NC=C3)N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PHA 767491 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.97	100
	DMSO	24.97	100

Preparing Stock Solutions for PHA 767491 hydrochloride

The following data is based on the product molecular weight 249.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4 mL	20.02 mL	40.05 mL
5 mM	0.8 mL	4 mL	8.01 mL
10 mM	0.4 mL	2 mL	4 mL
50 mM	0.08 mL	0.4 mL	0.8 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for PHA 767491 hydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for PHA 767491 hydrochloride

References are publications that support the biological activity of the product.

Anderson et al (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J.Med.Chem. 50 2647 PMID: 17480064

Jackson (2008) Stopping replication, at the beginning. Nature Chem.Biol. 4 331 PMID: 18488006

Montagnoli et al (2008) A cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumour activity. Nature Chem.Biol. 4 357 PMID: 18469809

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for PHA 767491 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective CDK Inhibitors

Keywords: PHA 767491 hydrochloride, PHA 767491 hydrochloride supplier, Dual, cdc7/cdk9, inhibits, inhibitors, MK-2, mitogen-activated, protein, kinase-activated, kinase-2, Cyclin-Dependent, Protein, kinases, Checkpoint, control, PHA767491, hydrochloride, MK2, Cyclin-dependent, Kinase, Non-selective, CDKs, 3140, Tocris Bioscience