PG 931

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Cat.No. 5094 - PG 931 | Ac-Nle-cyclo(Asp-Pro-D-Phe-Arg-Trp-Lys)-Pro-Val-NH2 | CAS No. 667430-81-1
Description: Potent and selective MC4 receptor agonist
Datasheet
Citations

Biological Activity

Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats.

Technical Data

M. Wt 1180.41
Formula C59H85N15O11
Sequence XDPFRWKPV

(Modifications: X-1 = Ac-Nle, Phe-4 = D-Phe, Val-9 = C-terminal amide, Asp-2, Lys-7, Cyclized)

Storage Store at -20°C
CAS Number 667430-81-1
PubChem ID 90489007
InChI Key WOFDJLFPEWSAPJ-RVBGBMFGSA-N
Smiles CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H]2CCCN2C1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 25% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1180.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.24 mL 8.47 mL
5 mM 0.17 mL 0.85 mL 1.69 mL
10 mM 0.08 mL 0.42 mL 0.85 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Giuliani et al (2007) Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br.J.Pharmacol. 150 595 PMID: 17245369

Grieco et al (2003) Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J.Pept.Res. 62 199 PMID: 14531843


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Keywords: PG931 Potent selective MC4R receptors agonists Melanocortin Melanocortin (MC) Receptor Peptide

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