PG 106

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Cat.No. 4919 - PG 106 | Ac-Nle-cyclo(Asp-beta-Ala-D-2-Nal-Arg-Trp-Lys)-NH2 | CAS No. 944111-22-2
Description: Selective MC3 receptor antagonist
Datasheet
Citations

Biological Activity

Selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.

Technical Data

M. Wt 1008.19
Formula C51H69N13O9
Sequence XDXXRWK

(Modifications: X-1 = Ac-Nle, X-3 = beta-Ala, X-4 = D-2-Nal, Lys-7 = C-terminal amide, Asp-2, Lys-7, Cyclized)

Storage Store at -20°C
CAS Number 944111-22-2
PubChem ID 90488990
InChI Key ZFZDDBJAFMOQSH-JHMPFZGISA-N
Smiles [H]N([C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)CCNC1=O)C(N)=O)C(=O)C(CCCC)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 25% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1008.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.96 mL 9.92 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.5 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Grieco et al (2007) Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28 1191 PMID: 17482720


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View Related Products by Target

Keywords: PG106 MC3 melanocortin receptors antagonists Melanocortin (MC) Receptor Peptide

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