PG 106

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Cat.No. 4919 - PG 106 | Ac-Nle-cyclo(Asp-beta-Ala-D-2-Nal-Arg-Trp-Lys)-NH2 | CAS No. 944111-22-2
Description: Selective MC3 receptor antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.

Technical Data

M. Wt 1008.19
Formula C51H69N13O9
Sequence XDXXRWK

(Modifications: X-1 = Ac-Nle, X-3 = beta-Ala, X-4 = D-2-Nal, Lys-7 = C-terminal amide, Asp-2, Lys-7, Cyclized)

Storage Store at -20°C
CAS Number 944111-22-2
PubChem ID 90488990
InChI Key ZFZDDBJAFMOQSH-JHMPFZGISA-N
Smiles [H]N([C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)CCNC1=O)C(N)=O)C(=O)C(CCCC)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 25% ethanol / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Grieco et al (2007) Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28 1191 PMID: 17482720


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Keywords: PG 106, PG 106 supplier, PG106, MC3, melanocortin, receptors, antagonists, Melanocortin, Receptors, 4919, Tocris Bioscience

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Literature in this Area

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