PG 106

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Cat.No. 4919 - PG 106 | Ac-Nle-cyclo(Asp-beta-Ala-D-2-Nal-Arg-Trp-Lys)-NH2 | CAS No. 944111-22-2
Description: Selective MC3 receptor antagonist
Literature (3)

Biological Activity for PG 106

PG 106 is a selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.

Technical Data for PG 106

M. Wt 1008.19
Formula C51H69N13O9
Sequence XDXXRWK

(Modifications: X-1 = Ac-Nle, X-3 = beta-Ala, X-4 = D-2-Nal, Lys-7 = C-terminal amide, Asp-2, Lys-7, Cyclized)

Storage Store at -20°C
CAS Number 944111-22-2
PubChem ID 90488990
Smiles [H]N([C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)CCNC1=O)C(N)=O)C(=O)C(CCCC)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PG 106

Solubility Soluble to 1 mg/ml in 25% ethanol / water

Product Datasheets for PG 106

Certificate of Analysis / Product Datasheet
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References for PG 106

References are publications that support the biological activity of the product.

Grieco et al (2007) Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28 1191 PMID: 17482720

If you know of a relevant reference for PG 106, please let us know.

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Keywords: PG 106, PG 106 supplier, PG106, MC3, melanocortin, receptors, antagonists, Melanocortin, Receptors, 4919, Tocris Bioscience

Citations for PG 106

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