PG 106

Pricing Availability Delivery Time Qty
Cat.No. 4919 - PG 106 | Ac-Nle-cyclo(Asp-beta-Ala-D-2-Nal-Arg-Trp-Lys)-NH2 | CAS No. 944111-22-2
Description: Selective MC3 receptor antagonist

Biological Activity

Selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.

Technical Data

M. Wt 1008.19
Formula C51H69N13O9
Sequence XDXXRWK

(Modifications: X-1 = Ac-Nle, X-3 = beta-Ala, X-4 = D-2-Nal, Lys-7 = C-terminal amide, Asp-2, Lys-7, Cyclized)

Storage Store at -20°C
CAS Number 944111-22-2
PubChem ID 90488990
Smiles [H]N([C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)CCNC1=O)C(N)=O)C(=O)C(CCCC)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 25% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1008.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.96 mL 9.92 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.5 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Grieco et al (2007) Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28 1191 PMID: 17482720

If you know of a relevant reference for PG 106, please let us know.

View Related Products by Target

Keywords: PG106 MC3 melanocortin receptors antagonists Melanocortin (MC) Receptor Peptide

Citations for PG 106

Citations are publications that use Tocris products.

Currently there are no citations for PG 106. Do you know of a great paper that uses PG 106 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area

Pathways for PG 106


TODO: Add Protocols