PF 750

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Cat.No. 3307 - PF 750 | C22H23N3O | CAS No. 959151-50-9
Description: Selective FAAH inhibitor
Chemical Name: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 16.2 nM) that displays no activity at a range of other serine hydrolases. Selectively inhibits FAAH within the central nervous system. Orally active.

Compound Libraries

PF 750 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 345.44
Formula C22H23N3O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 959151-50-9
PubChem ID 25154868
InChI Key BIODYGOZWZNCAG-UHFFFAOYSA-N
Smiles O=C(NC4=CC=CC=C4)N(CC3)CCC3CC2=CC1=CC=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.54 100
ethanol 34.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 345.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.47 mL 28.95 mL
5 mM 0.58 mL 2.89 mL 5.79 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ahn et al (2007) Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46 13019 PMID: 17949010

Mileni et al (2008) Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc.Natl.Acad.Sci.USA 105 12820 PMID:


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View Related Products by Product Action

View all Fatty Acid Amide Hydrolase Inhibitors

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Citations for PF 750

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