PF 750

Discontinued Product

PF 750 (Cat. No. 3307) has been withdrawn from sale for commercial reasons.
Description: Selective FAAH inhibitor
Chemical Name: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for PF 750

PF 750 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor (IC50 = 16.2 nM) that displays no activity at a range of other serine hydrolases. Selectively inhibits FAAH within the central nervous system. Orally active.

Technical Data for PF 750

M. Wt 345.44
Formula C22H23N3O
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 959151-50-9
PubChem ID 25154868
InChI Key BIODYGOZWZNCAG-UHFFFAOYSA-N
Smiles O=C(NC4=CC=CC=C4)N(CC3)CCC3CC2=CC1=CC=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PF 750

References are publications that support the biological activity of the product.

Ahn et al (2007) Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry 46 13019 PMID: 17949010

Mileni et al (2008) Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc.Natl.Acad.Sci.USA 105 12820

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Citations for PF 750

Citations are publications that use Tocris products.

Currently there are no citations for PF 750.

Reviews for PF 750

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.