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PF 6274484

Cat. No. 5939 Submit a Review Datasheet / COA / SDS

Discontinued Product

PF 6274484 (Cat. No. 5939) has been withdrawn from sale for commercial reasons.
Description: High affinity and potent covalent EGFR kinase inhibitor
Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for PF 6274484

PF 6274484 is a high affinity and potent covalent EGFR kinase inhibitor (Ki = 0.14 nM). Inhibits autophosphorylation of WT and mutant EGFR in tumor cells (IC50 values are 5.8 and 6.6 nM, respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 6274484

M. Wt 372.78
Formula C18H14ClFN4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1035638-91-5
PubChem ID 74766099
InChI Key TUYDDIWQXWTNSW-UHFFFAOYSA-N
Smiles COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1NC(C=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for PF 6274484

References are publications that support the biological activity of the product.

Schwartz et al (2014) Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc.Natl.Acad.Sci.U.S.A. 111 173 PMID: 24347635

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Citations for PF 6274484

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Currently there are no citations for PF 6274484.

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