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High affinity and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 452.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.21 mL||11.06 mL||22.11 mL|
|5 mM||0.44 mL||2.21 mL||4.42 mL|
|10 mM||0.22 mL||1.11 mL||2.21 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the biological activity of the product.
Dow et al (2009) Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of J.Med.Chem. 52 2652 PMID: 19351113
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Keywords: PF 514273, PF 514273 supplier, Potent, and, selective, CB1, agonists, cannabinoids, Receptors, PF514273, cb1r, 3676, Tocris Bioscience
1 Citation for PF 514273
Citations are publications that use Tocris products. Selected citations for PF 514273 include:
Rozenfeld et al (2011) AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 30 2350 PMID: 21540834
Do you know of a great paper that uses PF 514273 from Tocris? Please let us know.
Reviews for PF 514273
Average Rating: 4 (Based on 1 Review.)
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Used in vivo for mouse behavioral work to test CB1 receptor involvement in alcohol reward learning and seeking behavior. Data show product did work centrally, as it reduced locomotor activity.
Drug can be difficult to get into solution, as would be expected for a cannabinoid compound. So don't expect to use high concentrations unless you are OK w/ using in suspension.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.