PF 514273

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Cat.No. 3676 - PF 514273 | C21H17Cl2F2N3O2 | CAS No. 851728-60-4
Description: Potent and selective CB1 antagonist
Chemical Name: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective CB1 receptor antagonist (Ki values are 1 and > 10000 nM at CB1 and CB2 receptors respectively). Inhibits food intake in vivo following oral administration.

Technical Data

M. Wt 452.28
Formula C21H17Cl2F2N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 851728-60-4
PubChem ID 11316919
InChI Key FJMQJSUOOGOWBD-UHFFFAOYSA-N
Smiles O=C2C1=NN(C4=CC=CC=C4Cl)C(C3=CC=C(Cl)C=C3)=C1OCCN2CC(C)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.23 100
ethanol 22.61 50

Preparing Stock Solutions

The following data is based on the product molecular weight 452.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.06 mL 22.11 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dow et al (2009) iscovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazole[3,4-f][1,4]oxazepin-8-(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of J.Med.Chem. 52 2652 PMID: 19351113


If you know of a relevant reference for PF 514273, please let us know.

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Keywords: Potent and selective CB1 agonists cannabinoids Receptors PF514273 cb1r CB1 Receptors

1 Citation for PF 514273

Citations are publications that use Tocris products. Selected citations for PF 514273 include:

Rozenfeld et al (2011) AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 30 2350 PMID: 21540834


Do you know of a great paper that uses PF 514273 from Tocris? If so please let us know.

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