PF 4981517

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Cat.No. 4252 - PF 4981517 | C26H32N8 | CAS No. 1390637-82-7
Description: Selective CYP3A4 inhibitor
Chemical Name: (1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)
Purity: ≥98% (HPLC)

Biological Activity for PF 4981517

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 4981517

M. Wt 456.59
Formula C26H32N8
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1390637-82-7
PubChem ID 71315139
Smiles CN1N=C(C5=C(C6=CC=C(C)C=C6)N(C)N=C5)C2=C1N=CN=C2N3C[C@@H](N4CCCCC4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PF 4981517

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.66 100
ethanol 9.13 20

Preparing Stock Solutions for PF 4981517

The following data is based on the product molecular weight 456.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.95 mL 21.9 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for PF 4981517

References are publications that support the biological activity of the product.

Walsky et al (2012) Selective mechanism-based inactivation of cytochrome P4503A4 by cyp3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of cytochrome P4503A4 versus P4503A5 in the metabolism of drugs. Am.Soc.Pharmacol.Exp.Ther. Epub ahead of print

If you know of a relevant reference for PF 4981517, please let us know.

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