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Biological Activity for PETCM
PETCM is a caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
Technical Data for PETCM
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PETCM
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PETCM
The following data is based on the product molecular weight 240.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.32 mL||41.58 mL||83.15 mL|
|2.5 mM||1.66 mL||8.32 mL||16.63 mL|
|5 mM||0.83 mL||4.16 mL||8.32 mL|
|25 mM||0.17 mL||0.83 mL||1.66 mL|
References for PETCM
References are publications that support the biological activity of the product.
Jiang et al (2003) Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299 223 PMID: 12522243
Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.U.S.A. 100 7533 PMID: 12808146
If you know of a relevant reference for PETCM, please let us know.
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Keywords: PETCM, PETCM supplier, activators, caspase-3, Caspases, Proteinases, Proteases, Enzyme, Substrates, /, Activators, 1758, Tocris Bioscience
Citations for PETCM
Citations are publications that use Tocris products.
Currently there are no citations for PETCM. Do you know of a great paper that uses PETCM from Tocris? Please let us know.
Reviews for PETCM
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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