PETCM

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Cat.No. 1758 - PETCM | C8H8Cl3NO | CAS No. 10129-56-3
Description: Activator of caspase-3
Chemical Name: α-(Trichloromethyl)-4-pyridineethanol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.

Technical Data

M. Wt 240.52
Formula C8H8Cl3NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 10129-56-3
PubChem ID 224859
InChI Key NGTDJJKTGRNNAU-UHFFFAOYSA-N
Smiles OC(CC1=CC=NC=C1)C(Cl)(Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 12.03 50

Preparing Stock Solutions

The following data is based on the product molecular weight 240.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.16 mL 20.79 mL 41.58 mL
5 mM 0.83 mL 4.16 mL 8.32 mL
10 mM 0.42 mL 2.08 mL 4.16 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jiang et al (2003) Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299 223 PMID: 12522243

Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.U.S.A. 100 7533 PMID: 12808146


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Keywords: activators caspase-3 Caspases Proteinases Proteases Caspases

Citations for PETCM

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Pathways for PETCM

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