Caspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent manner.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 240.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.16 mL||20.79 mL||41.58 mL|
|5 mM||0.83 mL||4.16 mL||8.32 mL|
|10 mM||0.42 mL||2.08 mL||4.16 mL|
|50 mM||0.08 mL||0.42 mL||0.83 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Jiang et al (2003) Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299 223 PMID: 12522243
Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.U.S.A. 100 7533 PMID: 12808146
If you know of a relevant reference for PETCM, please let us know.
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Keywords: activators caspase-3 Caspases Proteinases Proteases Caspases
Citations for PETCM
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