Perindopril erbumine

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Cat.No. 4302 - Perindopril erbumine | C19H32N2O5.C4H11N | CAS No. 107133-36-8
Description: Angiotensin-converting enzyme (ACE) inhibitor
Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity

Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.

Technical Data

M. Wt 441.6
Formula C19H32N2O5.C4H11N
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 107133-36-8
PubChem ID 441313
Smiles C[C@H](N[C@H]([C@@](OCC)=O)CCC)C(N1[C@H]([C@@](O)=O)C[C@@]2([H])[C@@]([H])1CCCC2)=O.NC(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 22.08 50

Preparing Stock Solutions

The following data is based on the product molecular weight 441.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.53 mL 22.64 mL 45.29 mL
2.5 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

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References are publications that support the biological activity of the product.

Takai et al (2004) Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens.Res. 27 213 PMID: 15080380

Ceconi et al (2007) Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur.J.Pharmacol. 577 1 PMID: 17716647

Dong et al (2011) Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. 25 2911 PMID: 21593435

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Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
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  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
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