pep2m

Pricing Availability Delivery Time Qty
Cat.No. 1595 - pep2m | Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln | CAS No. 243843-42-7
Description: Peptide inhibitor of GluR2 subunit binding to NSF. Reduces AMPA currents
Alternative Names: GluR2m, G10
Datasheet
Citations (1)
Literature

Biological Activity

Peptide inhibitor of the interaction between the C-terminus of the GluR2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces postsynaptic currents in CA1 neurons, AMPA-mediated currents in cultured hippocampal neurons and AMPA receptor surface expression. Control peptide pep4c (Cat. No. 1596) also available.

Technical Data

M. Wt 1173.44
Formula C49H92N18O13S
Sequence KRMKVAKNAQ
Storage Desiccate at -20°C
CAS Number 243843-42-7
PubChem ID 90479806
InChI Key DTYSOEUWYZLCBY-MFTMZZJWSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 20% acetonitrile

Preparing Stock Solutions

The following data is based on the product molecular weight 1173.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.26 mL 8.52 mL
5 mM 0.17 mL 0.85 mL 1.7 mL
10 mM 0.09 mL 0.43 mL 0.85 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Collingridge and Isaac (2003) Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 47 3 PMID: 12941441

Luscher et al (1999) Role of AMPA receptor cycling in synaptic transmission and plasticity. Neuron 24 649 PMID: 10595516

Luthi et al (1999) Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron 24 389 PMID: 10571232

Nishimune et al (1998) NSF binding to GluR2 regulates synaptic transmission. Neuron 21 87 PMID: 9697854

Noel et al (1999) Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron 23 365 PMID: 10399941


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Keywords: Peptide inhibitors inhibits GluR2 subunit binding NSF N-ethylmaleimide-sensitive fusion protein Reduces AMPA currents Glutamate Receptors iGlur Ionotropic GluR2m G10 AMPA Receptors

1 Citation for pep2m

Citations are publications that use Tocris products. Selected citations for pep2m include:

Yao et al (2008) PKM ΞΆ maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptors. Proc Natl Acad Sci U S A 28 7820 PMID: 18667614


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Pathways for pep2m

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