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Cat.No. 3056 - Pentoxifylline | C13H18N4O3 | CAS No. 6493-05-6
Description: PDE inhibitor
Alternative Names: PTX
Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine
Purity: ≥99% (HPLC)
Citations (14)

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.

Technical Data

M. Wt 278.31
Formula C13H18N4O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6493-05-6
PubChem ID 4740
Smiles O=C(C(N(C)C=N2)=C2N1C)N(CCCCC(C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 278.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.97 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Monshouwer et al (1996) Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem.Pharmacol. 52 1195 PMID: 8937426

Vale et al (2004) Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. Br.J.Pharmacol. 143 833 PMID: 15520047

If you know of a relevant reference for Pentoxifylline, please let us know.

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Keywords: Pentoxifylline, supplier, PDE, inhibitors, inhibits, Phosphodiesterases, PTX, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

14 Citations for Pentoxifylline

Citations are publications that use Tocris products. Selected citations for Pentoxifylline include:

Bailes et al (2012) Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. Dev Neurobiol 7 e30774 PMID: 22292038

Zhang and Sun (2011) Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Neuroscience 71 221 PMID: 20936660

Zhang et al (2011) Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex. Br J Pharmacol 174 45931 PMID: 21115101

Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286 PMID: 25850004

Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71 PMID: 26198357

Park (2015) Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. J Neurosci 2015 275126 PMID: 26617436

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Toxicol Sci 5 10468 PMID: 26020477

Thueson et al (2015) In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells. Sci Rep 143 418 PMID: 25433234

Wang et al (2015) β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure. Mediators Inflamm 5 7681 PMID: 25567365

Guidi et al (2015) Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors. PLoS One 35 3966 PMID: 25740525

Simonson et al (2015) Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Mol Biol Cell 172 515 PMID: 24641310

Penzo and Peña (2009) Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. J Neurosci 29 4131 PMID: 19339608

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047 PMID: 17178407

Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031 PMID: 15257286

Do you know of a great paper that uses Pentoxifylline from Tocris? If so please let us know.

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