Discontinued Product

Pentoxifylline (Cat. No. 3056) has been withdrawn from sale for commercial reasons.
Description: PDE inhibitor
Alternative Names: PTX
Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine
Purity: ≥99% (HPLC)
Citations (18)
Literature (1)

Biological Activity for Pentoxifylline

Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.

Technical Data for Pentoxifylline

M. Wt 278.31
Formula C13H18N4O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6493-05-6
PubChem ID 4740
Smiles O=C(C(N(C)C=N2)=C2N1C)N(CCCCC(C)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Pentoxifylline

Certificate of Analysis / Product Datasheet
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References for Pentoxifylline

References are publications that support the biological activity of the product.

Monshouwer et al (1996) Differential effect of pentoxify. on lipopolysaccharide-induced downregulation of cytochrome P450. Biochem.Pharmacol. 52 1195 PMID: 8937426

Vale et al (2004) Antihyperalgesic effect of pentoxify. on experimental inflammatory pain. Br.J.Pharmacol. 143 833 PMID: 15520047

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Keywords: Pentoxifylline, Pentoxifylline supplier, PDE, inhibitors, inhibits, Phosphodiesterases, PTX, 3056, Tocris Bioscience

18 Citations for Pentoxifylline

Citations are publications that use Tocris products. Selected citations for Pentoxifylline include:

Jakubs et al (2006) Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability. Neuron 52 1047 PMID: 17178407

Kumar and Foster (2013) Linking redox regulation of NMDAR synaptic function to cognitive decline during aging. J Neurosci 33 15710 PMID: 24089479

Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID: 20519319

Pierre et al (2004) PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. EMBO J 23 3031 PMID: 15257286

Penzo and Peña (2009) Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically. J Neurosci 29 4131 PMID: 19339608

Wang et al (2017) Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism. J Clin Invest 127 1978 PMID: 28414301

Park (2015) Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. J Neurosci 2015 275126 PMID: 26617436

Zhang and Sun (2011) Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Neuroscience 71 221 PMID: 20936660

Feng et al (2015) Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings. J Neurophysiol 113 2618 PMID: 25652923

Malyshev et al (2015) Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding. PLoS One 10 e0122286 PMID: 25850004

Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71 PMID: 26198357

Zhang et al (2011) Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex. Br J Pharmacol 174 45931 PMID: 21115101

Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Toxicol Sci 5 10468 PMID: 26020477

Thueson et al (2015) In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells. Sci Rep 143 418 PMID: 25433234

Wang et al (2015) β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure. Mediators Inflamm 5 7681 PMID: 25567365

Guidi et al (2015) Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors. PLoS One 35 3966 PMID: 25740525

Simonson et al (2015) Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. Mol Biol Cell 172 515 PMID: 24641310

Bailes et al (2012) Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. Dev Neurobiol 7 e30774 PMID: 22292038

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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  • Atherosclerosis
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