PD 153035 hydrochloride

Discontinued Product

PD 153035 hydrochloride (Cat. No. 1037) has been withdrawn from sale for commercial reasons.
Description: EGFR-kinase inhibitor
Alternative Names: ZM 252868
Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Datasheet
Citations (5)
Reviews
Literature (1)

Biological Activity for PD 153035 hydrochloride

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for PD 153035 hydrochloride

M. Wt 396.67
Formula C16H14BrN3O2.HCl
Storage Store at RT
CAS Number 183322-45-4
PubChem ID 11246488
InChI Key ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Smiles BrC1=CC=CC(NC3=NC=NC2=CC(OC)=C(OC)C=C23)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PD 153035 hydrochloride

Certificate of Analysis / Product Datasheet
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5 Citations for PD 153035 hydrochloride

Citations are publications that use Tocris products. Selected citations for PD 153035 hydrochloride include:

Taylor et al (2014) Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Res Treat 144 551 PMID: 24610032

Swanson et al (2012) Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol 188 3513 PMID: 22393153

Lahey et al (2017) Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS One 12 e0180259 PMID: 28671992

Marshall et al (2018) Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel) 5 PMID: 30373192


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Literature in this Area

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