PD 153035 hydrochloride

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Cat.No. 1037 - PD 153035 hydrochloride | C16H14BrN3O2.HCl | CAS No. 183322-45-4
Description: EGFR-kinase inhibitor
Alternative Names: ZM 252868
Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 396.67
Formula C16H14BrN3O2.HCl
Storage Store at RT
CAS Number 183322-45-4
PubChem ID 11246488
InChI Key ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Smiles BrC1=CC=CC(NC3=NC=NC2=CC(OC)=C(OC)C=C23)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.97 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 396.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.6 mL 25.21 mL
5 mM 0.5 mL 2.52 mL 5.04 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bos et al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099 PMID: 9815602

Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267 PMID: 8568816

Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093 PMID: 8066447


If you know of a relevant reference for PD 153035 hydrochloride, please let us know.

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View all EGFR Inhibitors

Keywords: PD 153035 hydrochloride, supplier, EGFR-kinase, inhibitors, inhibits, Epidermal, Growth, Factors, Receptors, ErbB, Her, Receptor, Tyrosine, Kinases, RTKs, PD153035, hydrochloride, AstraZeneca, ZM252868, ZM, 252868, EGFR, EGFR, Tocris Bioscience

1 Citation for PD 153035 hydrochloride

Citations are publications that use Tocris products. Selected citations for PD 153035 hydrochloride include:

Swanson et al (2012) Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol 188 3513 PMID: 22393153


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