PD 118057

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Cat.No. 2830 - PD 118057 | C21H17Cl2NO2 | CAS No. 313674-97-4
Description: Selective KV11.1 (hERG) channel activator
Chemical Name: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (5)

Biological Activity

Human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.

Compound Libraries

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Technical Data

M. Wt 386.27
Formula C21H17Cl2NO2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 313674-97-4
PubChem ID 9864959
InChI Key ZCQOSCDABPVAFB-UHFFFAOYSA-N
Smiles ClC(C(Cl)=C3)=CC=C3CCC(C=C2)=CC=C2NC1=C(C(O)=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.63 100
ethanol 7.73 20

Preparing Stock Solutions

The following data is based on the product molecular weight 386.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.89 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References

References are publications that support the biological activity of the product.

Zhou et al (2005) Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol.Pharmacol. 68 876 PMID: 15976038

Yeung and Greenwood (2007) Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am.J.Physiol.Cell.Physiol. 292 C468 PMID: 16870833

Duff (2008) hERG: The long and short of it. Heart Rhythm 5 591 PMID: 18362028


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Keywords: PD 118057, PD 118057 supplier, Human, ether-a-go-go, hERG, K+, potassium, KV, channels, activators, voltage-gated, voltage-dependent, PD118057, KV11.1, Voltage-Gated, Potassium, Channels, 2830, Tocris Bioscience

Citations for PD 118057

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Currently there are no citations for PD 118057. Do you know of a great paper that uses PD 118057 from Tocris? Please let us know.

Reviews for PD 118057

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Amazing Kv channel activator.
By Anonymous on 10/23/2018
Assay Type: In Vitro
Species: Human

Amazing Kv channel activator, shows high channel activation on almost all cell lines that express Kv channels. Performs great on experimental conditions, is stable and would buy again soon.

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