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Submit ReviewPD 118057
Discontinued Product
2830 has been discontinued.
View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
Description: Selective KV11.1 (hERG) channel activator
Chemical Name: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Biological Activity for PD 118057
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.
Technical Data for PD 118057
| M. Wt | 386.27 |
| Formula | C21H17Cl2NO2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 2830313674-97-4 |
| PubChem ID | 9864959 |
| InChI Key | ZCQOSCDABPVAFB-UHFFFAOYSA-N |
| Smiles | ClC(C(Cl)=C3)=CC=C3CCC(C=C2)=CC=C2NC1=C(C(O)=O)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PD 118057
References for PD 118057
References are publications that support the biological activity of the product.
Zhou et al (2005) Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol.Pharmacol. 68 876 PMID: 15976038
Yeung and Greenwood (2007) Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells. Am.J.Physiol.Cell.Physiol. 292 C468 PMID: 16870833
Duff (2008) hERG: The long and short of it. Heart Rhythm 5 591 PMID: 18362028
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Keywords: PD 118057, PD 118057 supplier, Human, ether-a-go-go, hERG, K+, potassium, KV, channels, activators, voltage-gated, voltage-dependent, PD118057, KV11.1, Voltage-Gated, Potassium, Channels, 2830, Tocris Bioscience
Citations for PD 118057
Citations are publications that use Tocris products.
Currently there are no citations for PD 118057.
Reviews for PD 118057
Average Rating: 5 (Based on 1 Review.)
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Amazing Kv channel activator.
By
Anonymous on 10/23/2018
Assay Type: In Vitro
Species: Human
Amazing Kv channel activator, shows high channel activation on almost all cell lines that express Kv channels. Performs great on experimental conditions, is stable and would buy again soon.
