PBP 10

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Cat.No. 4611 - PBP 10 | Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg | CAS No. 794466-43-6
Description: Selective FPR2 antagonist; cell permeable
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation.

Technical Data

M. Wt 1712.1
Formula C84H126N24O15
Sequence QRLFQVKGRR

(Modifications: Gln-1 = Rhodamine-B)

Storage Store at -20°C
CAS Number 794466-43-6
PubChem ID 16143872
InChI Key OIOWMSSANHIUTR-NVWDZAHRSA-N
Smiles CCN(CC)C1=CC2=C(C=C1)C(C1=CC=CC=C1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC([NH-])=N)C(O)=O)=C1C=CC(C=C1O2)=[N+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cunningham et al (2011) Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J.Biol.Chem. 276 43390 PMID: 11533030

Forsman et al (2012) Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J.Immunol. 189 629 PMID: 22706076

Courtin et al (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral.Res. 5 252 PMID: 28483551


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Keywords: PBP 10, PBP 10 supplier, PBP10, Polyphosphoinositide-Binding, Peptides, FPR1, FPR2, formyl, receptors, FPRL1, inhibitors, inhibits, antagonists, cell, permeable, antiviral, influenza, ERK, Formyl, Peptide, Receptors, Antivirals, 4611, Tocris Bioscience

2 Citations for PBP 10

Citations are publications that use Tocris products. Selected citations for PBP 10 include:

Sanders (2018) PLCζ Induced Ca2+ Oscillations in Mouse Eggs Involve a Positive Feedback Cycle of Ca2+ Induced InsP3 Formation From Cytoplasmic PIP2. Front. Cell Dev. Biol. 6 36 PMID: 29666796

Courtin (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral Research 143 252 PMID: 28483551


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Literature in this Area

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