PBP 10

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Cat.No. 4611 - PBP 10 | Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg | CAS No. 794466-43-6
Description: Selective FPR2 antagonist; cell permeable
Datasheet
Citations (1)
Literature

Biological Activity

Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation.

Technical Data

M. Wt 1712.1
Formula C84H126N24O15
Sequence QRLFQVKGRR

(Modifications: Gln-1 = Rhodamine-B)

Storage Store at -20°C
CAS Number 794466-43-6
PubChem ID 16143872
InChI Key OIOWMSSANHIUTR-NVWDZAHRSA-N
Smiles CCN(CC)C1=CC2=C(C=C1)C(C1=CC=CC=C1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC([NH-])=N)C(O)=O)=C1C=CC(C=C1O2)=[N+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1712.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.92 mL 5.84 mL
5 mM 0.12 mL 0.58 mL 1.17 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cunningham et al (2011) Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J.Biol.Chem. 276 43390 PMID: 11533030

Forsman et al (2012) Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J.Immunol. 189 629 PMID: 22706076

Courtin et al (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral.Res. 5 252 PMID: 28483551


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1 Citation for PBP 10

Citations are publications that use Tocris products. Selected citations for PBP 10 include:

Courtin (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral Research 143 252 PMID: 28483551


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GPCR

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