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Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation.
(Modifications: Gln-1 = Rhodamine-B)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Cunningham et al (2011) Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J.Biol.Chem. 276 43390 PMID: 11533030
Forsman et al (2012) Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J.Immunol. 189 629 PMID: 22706076
Courtin et al (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral.Res. 5 252 PMID: 28483551
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Keywords: PBP 10, PBP 10 supplier, PBP10, Polyphosphoinositide-Binding, Peptides, FPR1, FPR2, formyl, receptors, FPRL1, inhibitors, inhibits, antagonists, cell, permeable, antiviral, influenza, ERK, Formyl, Peptide, Receptors, Antivirals, Influenza, Viruses, 4611, Tocris Bioscience
3 Citations for PBP 10
Citations are publications that use Tocris products. Selected citations for PBP 10 include:
Courtin (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral Research 143 252 PMID: 28483551
Patel et al (2018) PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease. Nat Commun 9 5390 PMID: 30568254
Sanders (2018) PLCζ Induced Ca2+ Oscillations in Mouse Eggs Involve a Positive Feedback Cycle of Ca2+ Induced InsP3 Formation From Cytoplasmic PIP2. Front. Cell Dev. Biol. 6 36 PMID: 29666796
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