Paroxetine maleate

Pricing Availability   Qty
Description: Highly potent and selective 5-HT uptake inhibitor
Chemical Name: (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
Purity: ≥99% (HPLC)
Citations (7)
Literature (1)

Biological Activity for Paroxetine maleate

Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.

Technical Data for Paroxetine maleate

M. Wt 445.44
Formula C19H20FNO3.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 64006-44-6
PubChem ID 6435921
Smiles OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Paroxetine maleate

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 44.54 100
DMSO 44.54 100

Preparing Stock Solutions for Paroxetine maleate

The following data is based on the product molecular weight 445.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets for Paroxetine maleate

Certificate of Analysis / Product Datasheet
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References for Paroxetine maleate

References are publications that support the biological activity of the product.

Thomas et al (1987) Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 93 193 PMID: 2962217

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

Bourin et al (2001) Paroxetine: a review. CNS Drug Rev. 7 25 PMID: 11420571

Fujishiro et al (2002) Comparison of the anticholin. effects of the serotonergic antidepressants, paroxetine, fluvox. and clomipramine. Eur.J.Pharmacol. 454 183 PMID: 12421645

If you know of a relevant reference for Paroxetine maleate, please let us know.

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Keywords: Paroxetine maleate, Paroxetine maleate supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, serotonin, inhibitor, transporters, SERT, 5-Hydroxytryptamine, monoamine, neurotransmitter, Transporters, 2141, Tocris Bioscience

7 Citations for Paroxetine maleate

Citations are publications that use Tocris products. Selected citations for Paroxetine maleate include:

Steiner et al (2015) Interaction of parox. with mitochondrial proteins mediates neuroprotection. J Neurosci 12 200 PMID: 25404050

Zhou et al (2019) A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci 22 1649 PMID: 31451801

Mathes and Spector (2011) The selective serotonin reuptake inhibitor parox. does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats. Chem Senses 36 515 PMID: 21422376

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. BMC Neurosci 29 13909 PMID: 19890001

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.