Paroxetine maleate

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Cat.No. 2141 - Paroxetine maleate | C19H20FNO3.C4H4O4 | CAS No. 64006-44-6
Description: Highly potent and selective 5-HT uptake inhibitor
Chemical Name: (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.

Technical Data

M. Wt 445.44
Formula C19H20FNO3.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 64006-44-6
PubChem ID 6435921
InChI Key AEIUZSKXSWGSRU-QXGDPHCHSA-N
Smiles OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.54 100
ethanol 44.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.22 mL 22.45 mL
5 mM 0.45 mL 2.24 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Thomas et al (1987) Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 93 193 PMID: 2962217

Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305 PMID: 9400006

Bourin et al (2001) Paroxetine: a review. CNS Drug Rev. 7 25 PMID: 11420571

Fujishiro et al (2002) Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. Eur.J.Pharmacol. 454 183 PMID: 12421645


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Keywords: Paroxetine maleate, supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, serotonin, inhibitor, transporters, SERT, 5-Hydroxytryptamine, monoamine, neurotransmitter, 5-HT, Transporters, 5-HT, Transporters, Tocris Bioscience

2 Citations for Paroxetine maleate

Citations are publications that use Tocris products. Selected citations for Paroxetine maleate include:

Steiner et al (2015) Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. J Neurosci 12 200 PMID: 25404050

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. BMC Neurosci 29 13909 PMID: 19890001


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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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