Paprotrain

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Cat.No. 4813 - Paprotrain | C16H11N3 | CAS No. 57046-73-8
Description: Reversible inhibitor of MKLP-2
Chemical Name: (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Purity: ≥99% (HPLC)
Datasheet
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Literature

Biological Activity

Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

Technical Data

M. Wt 245.28
Formula C16H11N3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 57046-73-8
PubChem ID 12248889
InChI Key YMYYQRZCCKBFBE-MDWZMJQESA-N
Smiles N#C/C(C3=CNC2=CC=CC=C23)=C\C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.53 100
ethanol 2.45 10

Preparing Stock Solutions

The following data is based on the product molecular weight 245.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.08 mL 20.38 mL 40.77 mL
5 mM 0.82 mL 4.08 mL 8.15 mL
10 mM 0.41 mL 2.04 mL 4.08 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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References

References are publications that support the biological activity of the product.

Tcherniuk et al (2010) Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 49 8228 PMID: 20857469


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Keywords: Paprotrain, Paprotrain supplier, inhibitors, inhibits, MKLP-2, mitotic, kinesin-like, protein, 2, reversible, selective, Kinesin, 4813, Tocris Bioscience

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