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Cat.No. 4813 - Paprotrain | C16H11N3 | CAS No. 57046-73-8
Description: Reversible inhibitor of MKLP-2
Chemical Name: (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Purity: ≥99% (HPLC)

Biological Activity

Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

Technical Data

M. Wt 245.28
Formula C16H11N3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 57046-73-8
PubChem ID 12248889
Smiles N#C/C(C3=CNC2=CC=CC=C23)=C\C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.53 100
ethanol 2.45 10

Preparing Stock Solutions

The following data is based on the product molecular weight 245.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.08 mL 20.38 mL 40.77 mL
5 mM 0.82 mL 4.08 mL 8.15 mL
10 mM 0.41 mL 2.04 mL 4.08 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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References are publications that support the biological activity of the product.

Tcherniuk et al (2010) Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Agnew Chem.Int.Ed.Engl. 49 8228 PMID: 20857469

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Keywords: Paprotrain, Paprotrain supplier, inhibitors, inhibits, MKLP-2, mitotic, kinesin-like, protein, 2, reversible, selective, Kinesin, 4813, Tocris Bioscience

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